Bioengineered Protein Pores

Liviu Movileanu; Mohammad M. Mohammad

Bioengineered Protein Pores

Liviu Movileanu (Inventor), Mohammad M. Mohammad (Inventor)

Department of Physics

Research output: Patent

Abstract

A mutant Escherichia coli β-barrel monomeric protein pore bioengineered to remove a lumen-occluding domain and modify some of its extracellular domains. The modified protein, FhuA Δ/CΔ4L, forms a highly conductive pore as compared to other known pores and is capable of sensing large polypeptides and discriminating between modified protein analytes.

Original language	English (US)
Patent number	8,916,684
State	Published - Jan 5 2012

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title = "Bioengineered Protein Pores",

abstract = "A mutant Escherichia coli β-barrel monomeric protein pore bioengineered to remove a lumen-occluding domain and modify some of its extracellular domains. The modified protein, FhuA Δ/CΔ4L, forms a highly conductive pore as compared to other known pores and is capable of sensing large polypeptides and discriminating between modified protein analytes.",

author = "Liviu Movileanu and Mohammad, {Mohammad M.}",

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AU - Movileanu, Liviu

AU - Mohammad, Mohammad M.

PY - 2012/1/5

Y1 - 2012/1/5

N2 - A mutant Escherichia coli β-barrel monomeric protein pore bioengineered to remove a lumen-occluding domain and modify some of its extracellular domains. The modified protein, FhuA Δ/CΔ4L, forms a highly conductive pore as compared to other known pores and is capable of sensing large polypeptides and discriminating between modified protein analytes.

AB - A mutant Escherichia coli β-barrel monomeric protein pore bioengineered to remove a lumen-occluding domain and modify some of its extracellular domains. The modified protein, FhuA Δ/CΔ4L, forms a highly conductive pore as compared to other known pores and is capable of sensing large polypeptides and discriminating between modified protein analytes.

M3 - Patent

M1 - 8,916,684

ER -

Bioengineered Protein Pores

Abstract

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