Bifunctional chelates with mixed aromatic and aliphatic amine donors for labeling of biomolecules with the {Tc(CO)3}+ and {Re(CO)3}+ cores

Lihui Wei, John Babich, Jon Zubieta

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

A series of tridentate ligands consisting of mixed aromatic and aliphatic amine derivatives of single amino acid chelates and phenylpiperazine have been developed, and their reactions with [NEt4]2[ReBr 3(CO)3] have been investigated. The compounds [Re(CO) 3{(NC5H4CH2)NCH3(C 2H4)NHCH3}]Br (4), [Re(CO)3{(NC 5H4CH2)NCH3(C2H 4)NCH3(CH2)xCOOC2H 5}]Br (x = 1, 5; x = 4, 6) [Re(CO)3{(NC5H 4CH2)NH(C2H4)N(CH3) 2}]Br (7), [Re(CO)3{(NC5H4CH 2)N(CH 2COOC2H5)(C2H 4)N(CH3)2}]Br (8) and [Re(CO) 3(NC5H4CH2)(C2H 4NH2)N(CH2)3-CH3Ophenpip] Br (9) (phenpip: phenylpiperazine, -C6H4-(CH 2CH2)2N-) were prepared and characterized by elemental analysis, NMR, IR, HSMS and X-ray crystallography. All complexes exhibit fac-{Re(CO)3N3} coordination geometry in the cationic molecular unit. Crystal data for C13H17BrN 3O3Re (4): orthorhombic, Pbca, a = 13.4510(8) Å, b = 10.5728(6) Å, c = 22.5378(13) Å, V = 3205.2(3) Å3, Z = 8; C17H23BrN3O5Re (5): orthorhombic, Pcca, a = 16.5907(7) Å,b = 14.8387(6) Å, c = 16.7075(7) Å, V = 4113.1(3) Å3, Z = 8; C 13H25BrN3O7Re (7 • 4H 2O): monoclinic, P21/n, a = 14.0698(17) Å, b = 9.6760(12) Å, c = 15.6099 (19) Å, β = 114.930(2)°, V = 1927.1(4) Å3, Z = 4; C17H23BrN 3O5Re (8): monoclinic, P21/n, a = 7.5312(5) Å, b = 16.0366(10) Å, c = 16.8741(10) Å, β = 98.9990(10)°, V = 2012.9(2) Å3, Z = 4.

Original languageEnglish (US)
Pages (from-to)3691-3700
Number of pages10
JournalInorganica Chimica Acta
Volume358
Issue number13
DOIs
StatePublished - Sep 1 2005

Keywords

  • Bifunctional chelates
  • Complexes for nuclear imaging
  • Single amino acid chelates
  • {Tc(CO)} core complexes

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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