Bifunctional chelates with aliphatic amine donors for labeling of biomolecules with the {Tc(CO)3}+ and {Re(CO) 3}+ cores: The crystal and molecular structure of [Re(CO)3{(H2NCH2CH2)2 N(CH2)4CO2Me}]Br

Sangeeta Ray Banerjee, John W. Babich, Jon Zubieta

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

A general synthetic approach to the design of bis(ethylamine) derivatives of single amino acid chelates has been developed. In general, protection of diethylenetriamine as the phthalimide, followed by reaction with the appropriate bromoalkylcarboxylate and deprotection, yields the bifunctional reagents (H2NCH2CH2)2N-R-CO 2H. Reaction of the bis(aminoethyl)aminovaleric acid derivative with (NEt4)2[Re(CO)3Br3] in methanol yields [Re(CO)3{(H2NCH2CH2) 2N(CH2)4CO2Me}]Br (1Br), the first example of the {Re(CO)3}+ core ligated to exclusively aliphatic amine donors. Crystal data: C13H23BrN 3O5Re (1Br), monoclinic P21/c, a=8.3419(5) Å, b=9.4018(6) Å, c=23.569(1) Å, β=99.165(1)°, V=1824.9(2) Å3, Z=4, Dcalc=2.065 g cm-3.

Original languageEnglish (US)
Pages (from-to)481-484
Number of pages4
JournalInorganic Chemistry Communications
Volume7
Issue number4
DOIs
StatePublished - Apr 1 2004

Keywords

  • Bifunctional chelates
  • Single amino acid chelates
  • {M(CO)} core

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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