A bacteria-responsive shape memory polymer (SMP) platform with clinical impact for chronic wound infection control. A bacteria-responsive SMP is synthesized in a primary shape and then fixed in a secondary shape until exposed to a second stimulus, which comprises the presence of bacterial proteases. During active infection, bacteria release proteases that degrade peptides in the SMP backbone and induce recovery to the primary shape, thereby providing a visual indication of an infection. In addition, on the microscopic scale, the SMP shape change can help inhibit biofilm formation and make them more susceptible to treatment with antibiotics.
|Original language||English (US)|
|State||Published - Jun 22 2023|