Autistic spectrum disorders in velo-cardio facial syndrome (22q11.2 deletion)

Kevin M. Antshel; Alka Aneja; Leslie Strunge; Jena Peebles; Wanda P. Fremont; Kimberly Stallone; Nuria AbdulSabur; Anne Marie Higgins; Robert J. Shprintzen; Wendy R. Kates

doi:10.1007/s10803-006-0308-6

Autistic spectrum disorders in velo-cardio facial syndrome (22q11.2 deletion)

Kevin M. Antshel, Alka Aneja, Leslie Strunge, Jena Peebles, Wanda P. Fremont, Kimberly Stallone, Nuria AbdulSabur, Anne Marie Higgins, Robert J. Shprintzen, Wendy R. Kates

Research output: Contribution to journal › Article › peer-review

145 Scopus citations

Abstract

The extent to which the phenotype of children comorbid for velocardiofacial syndrome (VCFS) and autism spectrum disorders (ASD) differs from that of VCFS-only has not been studied. The sample consisted of 41 children (20 females) with VCFS, ranging in age from 6.5 years to 15.8 years. Eight children with VCFS met formal DSM-IV diagnostic criteria for autism based upon the ADI-R. These eight plus an additional nine participants met diagnostic criteria for an autistic spectrum disorder (VCFS + ASD). Ninety-four percent of the children with VCFS + ASD had a co-occurring psychiatric disorder while 60% of children with VCFS had a psychiatric disorder. Children with VCFS + ASD had larger right amygdala volumes. All other neuroanatomic regions of interest were statistically similar between the two groups.

Original language	English (US)
Pages (from-to)	1776-1786
Number of pages	11
Journal	Journal of Autism and Developmental Disorders
Volume	37
Issue number	9
DOIs	https://doi.org/10.1007/s10803-006-0308-6
State	Published - Oct 2007
Externally published	Yes

Keywords

22q11.2 deletion
Amygdala
Autism spectrum disorder
Velocardiofacial syndrome

ASJC Scopus subject areas

Developmental and Educational Psychology

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10.1007/s10803-006-0308-6

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title = "Autistic spectrum disorders in velo-cardio facial syndrome (22q11.2 deletion)",

abstract = "The extent to which the phenotype of children comorbid for velocardiofacial syndrome (VCFS) and autism spectrum disorders (ASD) differs from that of VCFS-only has not been studied. The sample consisted of 41 children (20 females) with VCFS, ranging in age from 6.5 years to 15.8 years. Eight children with VCFS met formal DSM-IV diagnostic criteria for autism based upon the ADI-R. These eight plus an additional nine participants met diagnostic criteria for an autistic spectrum disorder (VCFS + ASD). Ninety-four percent of the children with VCFS + ASD had a co-occurring psychiatric disorder while 60% of children with VCFS had a psychiatric disorder. Children with VCFS + ASD had larger right amygdala volumes. All other neuroanatomic regions of interest were statistically similar between the two groups.",

keywords = "22q11.2 deletion, Amygdala, Autism spectrum disorder, Velocardiofacial syndrome",

author = "Antshel, {Kevin M.} and Alka Aneja and Leslie Strunge and Jena Peebles and Fremont, {Wanda P.} and Kimberly Stallone and Nuria AbdulSabur and Higgins, {Anne Marie} and Shprintzen, {Robert J.} and Kates, {Wendy R.}",

note = "Funding Information: Acknowledgement This work was supported by NIH grants MH64824 and MH65481 to Wendy Kates.",

year = "2007",

month = oct,

doi = "10.1007/s10803-006-0308-6",

language = "English (US)",

volume = "37",

pages = "1776--1786",

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AU - Antshel, Kevin M.

AU - Aneja, Alka

AU - Strunge, Leslie

AU - Peebles, Jena

AU - Fremont, Wanda P.

AU - Stallone, Kimberly

AU - AbdulSabur, Nuria

AU - Higgins, Anne Marie

AU - Shprintzen, Robert J.

AU - Kates, Wendy R.

N1 - Funding Information: Acknowledgement This work was supported by NIH grants MH64824 and MH65481 to Wendy Kates.

PY - 2007/10

Y1 - 2007/10

N2 - The extent to which the phenotype of children comorbid for velocardiofacial syndrome (VCFS) and autism spectrum disorders (ASD) differs from that of VCFS-only has not been studied. The sample consisted of 41 children (20 females) with VCFS, ranging in age from 6.5 years to 15.8 years. Eight children with VCFS met formal DSM-IV diagnostic criteria for autism based upon the ADI-R. These eight plus an additional nine participants met diagnostic criteria for an autistic spectrum disorder (VCFS + ASD). Ninety-four percent of the children with VCFS + ASD had a co-occurring psychiatric disorder while 60% of children with VCFS had a psychiatric disorder. Children with VCFS + ASD had larger right amygdala volumes. All other neuroanatomic regions of interest were statistically similar between the two groups.

AB - The extent to which the phenotype of children comorbid for velocardiofacial syndrome (VCFS) and autism spectrum disorders (ASD) differs from that of VCFS-only has not been studied. The sample consisted of 41 children (20 females) with VCFS, ranging in age from 6.5 years to 15.8 years. Eight children with VCFS met formal DSM-IV diagnostic criteria for autism based upon the ADI-R. These eight plus an additional nine participants met diagnostic criteria for an autistic spectrum disorder (VCFS + ASD). Ninety-four percent of the children with VCFS + ASD had a co-occurring psychiatric disorder while 60% of children with VCFS had a psychiatric disorder. Children with VCFS + ASD had larger right amygdala volumes. All other neuroanatomic regions of interest were statistically similar between the two groups.

KW - 22q11.2 deletion

KW - Amygdala

KW - Autism spectrum disorder

KW - Velocardiofacial syndrome

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Autistic spectrum disorders in velo-cardio facial syndrome (22q11.2 deletion)

Abstract

Keywords

ASJC Scopus subject areas

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