Autistic spectrum disorders in velo-cardio facial syndrome (22q11.2 deletion)

Kevin M. Antshel, Alka Aneja, Leslie Strunge, Jena Peebles, Wanda P. Fremont, Kimberly Stallone, Nuria AbdulSabur, Anne Marie Higgins, Robert J. Shprintzen, Wendy R. Kates

Research output: Contribution to journalArticlepeer-review

144 Scopus citations


The extent to which the phenotype of children comorbid for velocardiofacial syndrome (VCFS) and autism spectrum disorders (ASD) differs from that of VCFS-only has not been studied. The sample consisted of 41 children (20 females) with VCFS, ranging in age from 6.5 years to 15.8 years. Eight children with VCFS met formal DSM-IV diagnostic criteria for autism based upon the ADI-R. These eight plus an additional nine participants met diagnostic criteria for an autistic spectrum disorder (VCFS + ASD). Ninety-four percent of the children with VCFS + ASD had a co-occurring psychiatric disorder while 60% of children with VCFS had a psychiatric disorder. Children with VCFS + ASD had larger right amygdala volumes. All other neuroanatomic regions of interest were statistically similar between the two groups.

Original languageEnglish (US)
Pages (from-to)1776-1786
Number of pages11
JournalJournal of Autism and Developmental Disorders
Issue number9
StatePublished - Oct 2007
Externally publishedYes


  • 22q11.2 deletion
  • Amygdala
  • Autism spectrum disorder
  • Velocardiofacial syndrome

ASJC Scopus subject areas

  • Developmental and Educational Psychology


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