Attenuation of morphine-induced behavioral changes in rodents by D- and L-glucose

Cheryl P. Talley, Gloria Arankowsky-Sandoval, Richard McCarty, Paul E. Gold

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Administration of D-glucose enhances learning and memory in several tasks and also attenuates memory impairments and other behavioral effects of several drugs, including morphine. The present experiment compared the effects of peripherally administered D-glucose with those of L-glucose, a stereoisomer of D-glucose that is not metabolized and does not readily cross the blood-brain barrier. Like D-glucose, though at somewhat different doses, peripherally administered L-glucose attenuated morphine-induced deficits in spontaneous alternation performance in rats and mice and attenuated morphine- induced hyperactivity in mice. L-Glucose did not raise circulating levels of plasma D-glucose, suggesting that the effects of L-glucose are not secondary to increased availability of D-glucose. Using direct injections of D- and L- glucose and morphine into the medial septum of rats, the findings indicate that D-glucose but not L-glucose attenuated morphine-induced deficits in spontaneous alternation performance; indeed, intraseptal injections of L- glucose alone impaired spontaneous alternation performance. These findings suggest that peripheral L-glucose antagonizes morphine-induced behavioral effects by a peripheral signaling mechanism, one distinct from the mechanisms that mediate at least some of the effects of D-glucose on brain function.

Original languageEnglish (US)
Pages (from-to)62-79
Number of pages18
JournalNeurobiology of Learning and Memory
Issue number1
StatePublished - Jan 1999
Externally publishedYes


  • D-glucose
  • L-glucose
  • Medial septum
  • Memory modulation
  • Spontaneous alternation

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


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