TY - JOUR
T1 - Attenuation of epileptogenesis
T2 - Proactive effect of a single epinephrine injection on amygdaloid kindling
AU - Welsh, Kathleen A.
AU - Gold, Paul E.
N1 - Funding Information:
Research supported by grants from the National Institutes of Mental Health (MH 31141) and Aging (AG 01642) and by a Biomedical Research Support grant from the University of Virginia. Send requests for reprints to Dr. Paul E. Gold. Center for the Neurobiotogy of Learning and Memory, University of California, Irvine, Calif. 92717.
PY - 1984/3
Y1 - 1984/3
N2 - Repeated daily electrical stimulation of the amygdala can lead to a progressive increase in brain and behavioral seizures. This phenomenon, termed kindling, has been viewed as a model for epileptogenesis. The results reported here demonstrate that a single systemic epinephrine injection can significantly retard such epileptogenesis for a period of at least several days. These findings suggest that peripheral catecholamines, responding either to stress near the time of seizure initiation or to treatments administered at that time, may be important in regulating the development of epileptic states. In addition, the results indicate that an acute episode of high plasma epinephrine levels may result in a durable modification of brain function.
AB - Repeated daily electrical stimulation of the amygdala can lead to a progressive increase in brain and behavioral seizures. This phenomenon, termed kindling, has been viewed as a model for epileptogenesis. The results reported here demonstrate that a single systemic epinephrine injection can significantly retard such epileptogenesis for a period of at least several days. These findings suggest that peripheral catecholamines, responding either to stress near the time of seizure initiation or to treatments administered at that time, may be important in regulating the development of epileptic states. In addition, the results indicate that an acute episode of high plasma epinephrine levels may result in a durable modification of brain function.
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U2 - 10.1016/S0163-1047(84)90279-6
DO - 10.1016/S0163-1047(84)90279-6
M3 - Article
C2 - 6732711
AN - SCOPUS:0021268446
SN - 0163-1047
VL - 40
SP - 179
EP - 185
JO - Behavioral and Neural Biology
JF - Behavioral and Neural Biology
IS - 2
ER -