TY - JOUR
T1 - Association of opioid misuse with anxiety and depression
T2 - A systematic review of the literature
AU - Rogers, Andrew H.
AU - Zvolensky, Michael J.
AU - Ditre, Joseph W.
AU - Buckner, Julia D.
AU - Asmundson, Gordon J.G.
N1 - Funding Information:
Julia D. Buckner: Dr. Buckner is an Associate Professor in the Department of Psychology at Louisiana State University as well as the Director of the LSU Anxiety & Addictive Behaviors Laboratory and Clinic. She is a licensed clinical psychologist with over 10 years of experience working with individuals who suffer from anxiety and/or substance use disorders. Her research focuses on understanding the etiology, maintenance, and treatment of anxiety, substance use, and co-occurring disorders. She has published over 100 professional works in this area. Her research has been funded by the National Institutes of Drug Abuse. Dr. Buckner has received numerous awards for her work in this area of interest from organizations such as the American Psychological Association, College on Problems of Drug Dependence, Anxiety Disorders Association of America, and the Association for Behavioral and Cognitive Therapies Addictive Behaviors & Anxiety Disorders Social Interest Groups.
Funding Information:
This work was supported by funding from the State of Texas funding. The State of Texas had no role in the study design, collection, analysis or interpretation of the data, writing the manuscript, or the decision to submit the paper for publication.
Funding Information:
Joseph W. Ditre: Dr. Ditre is an Associate Professor in the Department of Psychology at Syracuse University. He is a licensed clinical psychologist, and holds secondary appointments in the Department of Medicine at Upstate Medical University, and in the Center for Integrated Healthcare at the Syracuse VA Medical Center. He is also Director of the Pain and Addiction Research (PAR) Lab, which operates out of the Central New York Medical Center in Syracuse NY. Dr. Ditre’s research cuts across basic and applied work in the areas of health psychology and behavioral medicine, with an emphasis on the intersection of addictive behaviors and comorbid medical disorders. At the broadest level, this research examines how the use of substances may influence the onset and progression of comorbid medical disorders, and how the symptoms and sequelae of medical disorders may influence the use of addictive substances. More specifically, he has established a programmatic line of research that applies a multi-method approach to the study of complex interrelations between pain, affect, comorbid psychopathology, and the maintenance of addiction. Dr. Ditre’s program of research has been funded by National Institutes of Health since 2007, with a primary focus on conceptualizing and testing bi-directional relations between the experience of acute and chronic pain and the self-administration of nicotine, tobacco, alcohol, cannabis, and prescription opioids.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/3
Y1 - 2021/3
N2 - The opioid epidemic is a public health problem associated with a host of negative outcomes. Although clinicians recognize covariation between opioid misuse with anxiety and depressive symptoms and disorders, research on this topic has only recently accumulated. Progress in this domain is impeded by the lack of systematic and integrative research to better understand and treat these co-occurring problems. This paper represents the first attempt to systematically review the empirical literature examining relations between opioid use and misuse, and anxiety and depression. In the first section, we define key terms and describe the article selection strategy. In the second section, we review the prevalence of anxiety and depressive symptoms among individuals who use and misuse prescription and illicit opioids. In the third section, we review the magnitude of associations between anxiety and depressive symptoms and disorders with opioid misuse, as well as highlight studies examining the longitudinal and temporal sequence of the relations between these variables. In the fourth section, we focus on experimental therapeutics, reviewing what is known about individual difference and transdiagnostic vulnerability factors for anxiety and depression that might contribute to opioid misuse and its symptoms. Finally, we discuss current knowledge gaps and present a heuristic model to guide future research.
AB - The opioid epidemic is a public health problem associated with a host of negative outcomes. Although clinicians recognize covariation between opioid misuse with anxiety and depressive symptoms and disorders, research on this topic has only recently accumulated. Progress in this domain is impeded by the lack of systematic and integrative research to better understand and treat these co-occurring problems. This paper represents the first attempt to systematically review the empirical literature examining relations between opioid use and misuse, and anxiety and depression. In the first section, we define key terms and describe the article selection strategy. In the second section, we review the prevalence of anxiety and depressive symptoms among individuals who use and misuse prescription and illicit opioids. In the third section, we review the magnitude of associations between anxiety and depressive symptoms and disorders with opioid misuse, as well as highlight studies examining the longitudinal and temporal sequence of the relations between these variables. In the fourth section, we focus on experimental therapeutics, reviewing what is known about individual difference and transdiagnostic vulnerability factors for anxiety and depression that might contribute to opioid misuse and its symptoms. Finally, we discuss current knowledge gaps and present a heuristic model to guide future research.
KW - Opioid misuse
KW - anxiety
KW - comorbidity
KW - depression
KW - systematic review
UR - http://www.scopus.com/inward/record.url?scp=85099822624&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85099822624&partnerID=8YFLogxK
U2 - 10.1016/j.cpr.2021.101978
DO - 10.1016/j.cpr.2021.101978
M3 - Review article
C2 - 33515811
AN - SCOPUS:85099822624
SN - 0272-7358
VL - 84
JO - Clinical Psychology Review
JF - Clinical Psychology Review
M1 - 101978
ER -