A scheme for the two-step nucleophilic aroylation of α, β-unsaturated esters has been developed. The Michael reaction of an arylacetonitrile enolate with an α, β-unsaturated ester generally proceeds in good yield. Oxidative decyanation of the adduct affords clean γ-keto esters when the aryl substituent is not electron rich.
ASJC Scopus subject areas
- Organic Chemistry