Applying the floating-reference method to improve the precision of noninvasive blood glucose measurement

Wenliang Chen, Zhen Ma, Lin An, Kexin Xu

Research output: Chapter in Book/Entry/PoemConference contribution

8 Scopus citations


A new method, floating-reference, can efficiently reduce the influence of the physiological background variations on the blood glucose measurement by differentially processing two signals from reference point and measuring point. In this paper, the reference point, where the diffuse reflected light is not sensitive to the variation of glucose concentration, is theoretically proved. Then Monte Carlo simulations are applied to study the radial distribution of the diffuse reflectance at different glucose concentrations for the skin. Moreover, the experiments are constructed to measure the radial distribution of the diffuse reflectance by the intralipid solutions with different glucose concentrations. Both the results from simulation and experiment validate the existence of floating-reference point. By theoretically analyzing the background noises and their disturbing mode on the blood glucose detection, a novel data processing method based on the reference point is proposed to effectively extract the blood glucose information. And it is found from our preliminary experiments with intralipid samples that, this data processing method can reduce the influence of background variation on the extraction of real glucose signal and thus enhance the resolving capability on glucose concentration.

Original languageEnglish (US)
Title of host publicationOptical Diagnostics and Sensing VII
StatePublished - 2007
Externally publishedYes
EventOptical Diagnostics and Sensing VII - San Jose, CA, United States
Duration: Jan 23 2007Jan 24 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherOptical Diagnostics and Sensing VII
Country/TerritoryUnited States
CitySan Jose, CA


  • Floating-reference method
  • Glucose concentration
  • Noninvasive measurement
  • Reference point

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Applying the floating-reference method to improve the precision of noninvasive blood glucose measurement'. Together they form a unique fingerprint.

Cite this