Applications of shape memory polymers (SMPs) in mechanobiology and bone repair

J. H. Henderson; K. A. Davis; R. M. Baker

doi:10.1533/9780857098104.1.111

Applications of shape memory polymers (SMPs) in mechanobiology and bone repair

J. H. Henderson, K. A. Davis, R. M. Baker

Research output: Chapter in Book/Entry/Poem › Chapter

8 Scopus citations

Abstract

Shape memory polymers (SMPs) possess unique stiffness- and shape-changing functionality that is beginning to be applied both to study bone mechanobiology and to address limitations associated with current bone repair techniques. This chapter introduces SMPs and discusses their potential to be used as in vitro platforms for the study of bone cell mechanobiology, osteogenic differentiation, and bone model systems, and to be applied as in vivo scaffolds that can fill space, enable minimally invasive delivery, enable rapid load bearing, and self-anchor. A poly(. -caprolactone)-based SMP scaffold is used to demonstrate the feasibility and application of the concepts discussed.

Original language	English (US)
Title of host publication	Biomaterials for Bone Regeneration
Subtitle of host publication	Novel Techniques and Applications
Publisher	Elsevier
Pages	111-146
Number of pages	36
ISBN (Electronic)	9780857098108
ISBN (Print)	9780857098047
DOIs	https://doi.org/10.1533/9780857098104.1.111
State	Published - Jun 2 2014

Keywords

Bone
Critical-sized defect
Mechanobiology
Scaffold
Shape memory polymer (SMP)
Tissue engineering

ASJC Scopus subject areas

General Engineering
General Materials Science

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10.1533/9780857098104.1.111

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title = "Applications of shape memory polymers (SMPs) in mechanobiology and bone repair",

abstract = "Shape memory polymers (SMPs) possess unique stiffness- and shape-changing functionality that is beginning to be applied both to study bone mechanobiology and to address limitations associated with current bone repair techniques. This chapter introduces SMPs and discusses their potential to be used as in vitro platforms for the study of bone cell mechanobiology, osteogenic differentiation, and bone model systems, and to be applied as in vivo scaffolds that can fill space, enable minimally invasive delivery, enable rapid load bearing, and self-anchor. A poly(. -caprolactone)-based SMP scaffold is used to demonstrate the feasibility and application of the concepts discussed.",

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AU - Henderson, J. H.

AU - Davis, K. A.

AU - Baker, R. M.

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Y1 - 2014/6/2

N2 - Shape memory polymers (SMPs) possess unique stiffness- and shape-changing functionality that is beginning to be applied both to study bone mechanobiology and to address limitations associated with current bone repair techniques. This chapter introduces SMPs and discusses their potential to be used as in vitro platforms for the study of bone cell mechanobiology, osteogenic differentiation, and bone model systems, and to be applied as in vivo scaffolds that can fill space, enable minimally invasive delivery, enable rapid load bearing, and self-anchor. A poly(. -caprolactone)-based SMP scaffold is used to demonstrate the feasibility and application of the concepts discussed.

AB - Shape memory polymers (SMPs) possess unique stiffness- and shape-changing functionality that is beginning to be applied both to study bone mechanobiology and to address limitations associated with current bone repair techniques. This chapter introduces SMPs and discusses their potential to be used as in vitro platforms for the study of bone cell mechanobiology, osteogenic differentiation, and bone model systems, and to be applied as in vivo scaffolds that can fill space, enable minimally invasive delivery, enable rapid load bearing, and self-anchor. A poly(. -caprolactone)-based SMP scaffold is used to demonstrate the feasibility and application of the concepts discussed.

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KW - Critical-sized defect

KW - Mechanobiology

KW - Scaffold

KW - Shape memory polymer (SMP)

KW - Tissue engineering

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EP - 146

BT - Biomaterials for Bone Regeneration

PB - Elsevier

ER -

Applications of shape memory polymers (SMPs) in mechanobiology and bone repair

Abstract

Keywords

ASJC Scopus subject areas

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