Aortic reservoir function, estimated myocardial demand and coronary perfusion pressure following steady-state and interval exercise

A. D. Lane, K. S. Heffernan, L. M. Rossow, C. A. Fahs, S. M. Ranadive, H. Yan, T. Baynard, K. Wilund, B. Fernhall

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Aortic reservoir function is a measure of the aorta's ability to distribute blood during diastole, attenuating the pulsatility of blood flow, and is important in balancing cardiac flow. Effects of acute high versus moderate exercise intensity on reservoir function and cardiac energetics is unknown. Eighteen athletes completed a interval (INT) and steady-state (SS) cycling bout at 60% of VO2 peak. Reservoir function was calculated as the ratio of diastolic run-off to stroke volume and expressed as a percentage. Coronary perfusion pressure was derived from tissue Doppler imaging and echocardiography. Systolic tension-time integral (TTI) from the aortic pressure waveform served as a measure of myocardial oxygen consumption. All measures were made at rest, 30-min postexercise and 60-min postexercise. Average reservoir function before SS was 76%, which was reduced to 62% 30-min post-SS and 67% 60-min post-SS (P<0.05). Significantly greater reductions in reservoir function were seen following INT (from 71% pre-INT to 45% 30-min post-INT and 53% 60-min INT, P<0.05). Estimated coronary perfusion pressure was reduced 30 min following INT but not SS; both bouts reduced coronary perfusion pressure at 60-min postexercise (P<0.05). TTI increased following both INT and SS at 30- and 60-min postexercise with greater increases following INT (P<0.05). Following exercise, reservoir function was associated with TTI (P<0.05), but not coronary perfusion pressure (P>0.05). We conclude that reservoir function is attenuated following acute SS and INT, but these reductions were greater post-INT, suggesting that exercise intensity affects reservoir function. Reduction of reservoir function following exercise is related to TTI, a reflection of myocardial oxygen consumption but apparently not associated with coronary perfusion pressure.

Original languageEnglish (US)
Pages (from-to)353-360
Number of pages8
JournalClinical Physiology and Functional Imaging
Volume32
Issue number5
DOIs
StatePublished - Sep 1 2012

Keywords

  • Arterial compliance
  • Coronary perfusion
  • Interval training

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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