Antibacterial and Cytocompatible pH-Responsive Peptide Hydrogel

Dona Imanga Upamadi Edirisinghe, Areetha D’Souza, Maryam Ramezani, Robert J. Carroll, Quenten Chicón, Cheyene L. Muenzel, Jonathan Soule, Mary Beth Browning Monroe, Alison E. Patteson, Olga V. Makhlynets

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


A short peptide, FHHF-11, was designed to change stiffness as a function of pH due to changing degree of protonation of histidines. As pH changes in the physiologically relevant range, G′ was measured at 0 Pa (pH 6) and 50,000 Pa (pH 8). This peptide-based hydrogel is antimicrobial and cytocompatible with skin cells (fibroblasts). It was demonstrated that the incorporation of unnatural AzAla tryptophan analog residue improves the antimicrobial properties of the hydrogel. The material developed can have a practical application and be a paradigm shift in the approach to wound treatment, and it will improve healing outcomes for millions of patients each year.

Original languageEnglish (US)
Article number4390
Issue number11
StatePublished - Jun 2023


  • antimicrobial
  • cytocompatible
  • hydrogel
  • pH sensitive
  • rheology
  • self-healing
  • wound healing

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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