Anti-inflammatory mechanisms of polyphenols in adipose tissue: role of gut microbiota, intestinal barrier integrity and zinc homeostasis

Tariful Islam, Kembra Albracht-Schulte, Latha Ramalingam, Natalia Schlabritz-Lutsevich, Oak Hee Park, Masoud Zabet-Moghaddam, Nishan S. Kalupahana, Naima Moustaid-Moussa

Research output: Contribution to journalReview articlepeer-review

Abstract

Obesity is associated with an imbalance of micro-and macro-nutrients, gut dysbiosis, and a “leaky” gut phenomenon. Polyphenols, such as curcumin, resveratrol, and anthocyanins may alleviate the systemic effects of obesity, potentially by improving gut microbiota, intestinal barrier integrity (IBI), and zinc homeostasis. The essential micronutrient zinc plays a crucial role in the regulation of enzymatic processes, including inflammation, maintenance of the microbial ecology, and intestinal barrier integrity. In this review, we focus on IBI– which prevents intestinal lipopolysaccharide (LPS) leakage – as a critical player in polyphenol-mediated protective effects against obesity-associated white adipose tissue (WAT) inflammation. This occurs through mechanisms that block the movement of the bacterial endotoxin LPS across the gut barrier. Available research suggests that polyphenols reduce WAT and systemic inflammation via crosstalk with inflammatory NF-κB, the mammalian target of rapamycin (mTOR) signaling and zinc homeostasis.

Original languageEnglish (US)
Article number109242
JournalJournal of Nutritional Biochemistry
Volume115
DOIs
StatePublished - May 2023

Keywords

  • curcumin
  • gut microbiota
  • inflammation
  • obesity
  • polyphenols
  • zinc transporters

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Nutrition and Dietetics
  • Clinical Biochemistry

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