Analysis of acute naproxen administration on memory in young adults: A randomized, double-blind, placebo-controlled study

Jack H. Wilson, Amy Criss, Sean A. Spangler, Katherine Walukevich, Sandra Hewett

Research output: Contribution to journalArticle


Nonsteroidal anti-inflammatory drugs work by non-selectively inhibiting cyclooxygenase enzymes. Evidence indicates that metabolites of the cyclooxygenase pathway play a critical role in the process of learning and memory. We evaluated whether acute naproxen treatment impairs short-term working memory, episodic memory, or semantic memory in a young, healthy adult population. Participants received a single dose of placebo or naproxen (750 mg) in random order separated by 7-10 days. Two hours following administration, participants completed five memory tasks. The administration of acute high-dose naproxen had no effect on memory in healthy young adults.

Original languageEnglish (US)
Pages (from-to)1374-1376
Number of pages3
JournalJournal of Psychopharmacology
Issue number10
StatePublished - Oct 1 2017



  • episodic memory
  • memory
  • Naproxen
  • working memory
  • young adults

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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