An exploratory study of cardiac function and oxygen uptake during cycle ergometry in overweight children

Viswanath B. Unnithan, Tracy Baynard, Christopher R. Potter, Piers Barker, Kevin S. Heffernan, Erin Kelly, Greg Yates, Bo Fernhall

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objective: Obesity has been proposed to negatively impact cardiac function in overweight (OW) individuals. The relationship between diastolic dysfunction and oxygen uptake (V̇O2) kinetics is equivocal. This exploratory investigation evaluated the relationship between resting left ventricular function and V̇O2 kinetics during cycle ergometry in OW and non-overweight (NO) children and adolescents. Research Methods and Procedures: Fourteen OW (>85 percentile for BMI for age and gender) children, 10 boys and 4 girls (age, 11.7 ± 1.9 years; body mass, 80.6 ± 45.5 kg) and 10 NO children (4 boys, 6 girls) volunteered to participate in the study (age, 12.5 ± 2.1 years; body mass, 45.8 ± 13.8 kg). Resting cardiovascular structure and function were assessed using spectral Doppler echocardiography. All subjects underwent two sub-maximal exercise stages on a cycle ergometer (3 minutes unloaded and 5 minutes at 50 W, both at a cadence of 50 rpm). Respiratory data were measured on a breath-by-breath basis at both workloads and the mean response time (MRT) was calculated. Results: Analysis of the MRT data demonstrated that there were no significant differences between OW and NO (OW, 52.6 ± 11.7 seconds vs. NO, 45.6 ± 7.4 seconds). Significant correlations (p < 0.05) were obtained between MRT V̇O 2 and echocardiographic-derived mitral valve inflow pressure half-time (r = 0.55) and between MRT V̇O2, and mitral valve inflow deceleration time (r = 0.55). Discussion: The evidence from this research suggests a possible link between left ventricular diastolic function at rest and oxygen uptake kinetics during sub-maximal exercise in OW and NO children and adolescents.

Original languageEnglish (US)
Pages (from-to)2673-2682
Number of pages10
Issue number11
StatePublished - Nov 2007
Externally publishedYes


  • Cardiology
  • Exercise physiology
  • Overweight
  • Oxygen consumption
  • Pediatrics

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics


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