An acid-catalyzed macrolactonization protocol

Barry M. Trost, John D. Chisholm

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


(graph presented) An efficient macrolactonization protocol devoid of any base was developed derived from the use of vinyl esters in transesterification. Subjecting a hydroxy acid and ethoxyacetylene to 2 mol % [RuCl2(p-cymene)]2 in toluene followed by addition of camphorsulfonic acid or inverse addition provided macrolactones in good yields.

Original languageEnglish (US)
Pages (from-to)3743-3745
Number of pages3
JournalOrganic Letters
Issue number21
StatePublished - Oct 17 2002
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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