Abstract
(graph presented) An efficient macrolactonization protocol devoid of any base was developed derived from the use of vinyl esters in transesterification. Subjecting a hydroxy acid and ethoxyacetylene to 2 mol % [RuCl2(p-cymene)]2 in toluene followed by addition of camphorsulfonic acid or inverse addition provided macrolactones in good yields.
Original language | English (US) |
---|---|
Pages (from-to) | 3743-3745 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 4 |
Issue number | 21 |
DOIs | |
State | Published - Oct 17 2002 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry