An acid-catalyzed macrolactonization protocol

Barry M. Trost, John D. Chisholm

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

(graph presented) An efficient macrolactonization protocol devoid of any base was developed derived from the use of vinyl esters in transesterification. Subjecting a hydroxy acid and ethoxyacetylene to 2 mol % [RuCl2(p-cymene)]2 in toluene followed by addition of camphorsulfonic acid or inverse addition provided macrolactones in good yields.

Original languageEnglish (US)
Pages (from-to)3743-3745
Number of pages3
JournalOrganic Letters
Volume4
Issue number21
DOIs
StatePublished - Oct 17 2002

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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