(graph presented) An efficient macrolactonization protocol devoid of any base was developed derived from the use of vinyl esters in transesterification. Subjecting a hydroxy acid and ethoxyacetylene to 2 mol % [RuCl2(p-cymene)]2 in toluene followed by addition of camphorsulfonic acid or inverse addition provided macrolactones in good yields.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry