Amphetamine effects on long term potentiation in dentate granule cells

Richard L. Delanoy, Debara L. Tucci, Paul E. Gold

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Long term potentiation (LTP) has received considerable attention as a neurophysiological analog of memory. Amphetamine, as well as several other catecholamine agonists, can enhance behaviorally-assessed memory storage in a variety of training situations. The present experiments tested the effects of amphetamine on LTP produced by high frequency stimulation of the perforant path in rats. The results indicate that amphetamine can enhance the development of LTP under some but not all testing procedures. Studies of the neurobiological bases by which central and peripheral catecholamines modulate memory storage may be augmented by examinations of catecholamine effects on a specific form of long-lasting change in brain function. Similarly, the ability to manipulate LTP may prove to be an important aid in examinations of neurobiological correlates of this phenomenon.

Original languageEnglish (US)
Pages (from-to)137-139
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume18
Issue number1
DOIs
StatePublished - Jan 1983
Externally publishedYes

Keywords

  • Amphetamine
  • Catecholamines
  • Dentate granule cells
  • Long term potentiation
  • Memory modulation
  • Perforant pathway

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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