@article{5da6236e639d4f1b84ed6757bb560d32,
title = "Amnesia produced by unilateral, subseizure, electrical stimulation of the amygdala in rats",
abstract = "Rats were trained on a one-trial inhibitory (passive) avoidance task. Five seconds after the offset of the training footshock, animals received unilateral, subseizure electrical stimulation of the amygdala. When compared to either implanted or unimplanted control animals, those animals which received posttrial amygdala stimulation had a significant retention deficit. Histological examination of electrode placements indicated that maximal interference with retention was produced by stimulation of a small region of the amygdala in or near the basomedial nucleus. Increases in the stimulation train duration from 10 to 30 sec increased the degree of the retention deficit produced by the stimulation.",
author = "Gold, {Paul E.} and Edwards, {Rose Mary} and McGaugh, {James L.}",
note = "Funding Information: Recent evidence indicates that bilateral electrical stimulation of several subcortical regions produces retrograde amnesia (RA) (cf. Kesner and Wilburn, 1974; Gold, Zornetzer, and McGaugh, 1974). Of various subcortical regions which we have examined with posttrial bilateral subseizure stimulation, RA is most reliably produced with amygdala stimulation (McGaugh and Gold, 1973). Bilateral amygdala stimulation produces retrograde amnesia for inhibitory (passive) avoidance learning (McDonough and Kesner, 1971; Ilyutchenok and Vinnetsky, 197l; Gold, Macri, and McGaugh, 1973; Kesner and Conner, 1974), active avoidance learning (Handwerker, Gold, and McGaugh, 1974), and discriminated avoidance learning (Gold, Rose, Hankins, Spa.his, and McGaugh, 1975). These findings suggest that amygdala stimulation may interfere with memory processes occurring after avoidance training (Goddard, 1964). The present study examined the effect of posttrial unilateral amygdala stimulation on retention of an inhibitory avoidance response in rats. Other studies of the effect of unilateral amygdala stimulation indicate that acquisition is disrupted by stimulation administered during acquisition (Goddard, 1Supported by Research Grants MH 12526 and MH 25384 from the National Institute of Mental Health andGB 42746 from the National Science Foundation.",
year = "1975",
month = sep,
doi = "10.1016/S0091-6773(75)92131-8",
language = "English (US)",
volume = "15",
pages = "95--105",
journal = "Communications in behavioral biology. Part A: [Original articles]",
issn = "1074-7427",
publisher = "Academic Press Inc.",
number = "1",
}