@inproceedings{5d506377fdf6451ea2f9d4011f2db202,
title = "AGPDMS electrodes for single cell impedance spectroscopy",
abstract = "This paper presents a microfluidic device with wide channels and embedded AgPDMS electrodes for measuring the electrical properties of single cells. The work demonstrates the feasibility of using a large channel design and embedded electrodes for impedance spectroscopy to circumvent issues such as channel clogging and limited device re-usability. AgPDMS electrodes were formed on channel sidewalls for impedance detection and cell characterization. Equivalent circuit models were used to interpret multi-frequency impedance data to quantify each cell's cytoplasm conductivity and specific membrane capacitance. Comparisons were made by measuring two leukemia cell lines (AML-2 and HL-60) which were found to have different cytoplasm conductivity values (0.29 ± 0.15 S/m vs. 0.47 ± 0.20 S/m) and specific membrane capacitance values (41 ± 25 mF/m2 vs. 55 ± 26 mF/m2).",
author = "Yuan Wei and Cachia, {Mark A.} and John Nguyen and Zhensong Xu and Yi Zheng and Chen Wang and Yu Sun",
note = "Publisher Copyright: {\textcopyright} 2016 IEEE.; 29th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2016 ; Conference date: 24-01-2016 Through 28-01-2016",
year = "2016",
month = feb,
day = "26",
doi = "10.1109/MEMSYS.2016.7421723",
language = "English (US)",
series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "701--704",
booktitle = "MEMS 2016 - 29th IEEE International Conference on Micro Electro Mechanical Systems",
}