TY - JOUR
T1 - Aging reduces cerebral blood flow regulation following an acute hypertensive stimulus
AU - Rosenberg, Alexander J.
AU - Schroeder, Elizabeth C.
AU - Grigoriadis, Georgios
AU - Wee, Sang Ouk
AU - Bunsawat, Kanokwan
AU - Heffernan, Kevin S.
AU - Fernhall, Bo
AU - Baynard, Tracy
N1 - Publisher Copyright:
© 2020 American Physiological Society. All rights reserved.
PY - 2020/5
Y1 - 2020/5
N2 - Aging increases arterial stiffness, which has a negative impact on cerebral blood flow (CBF) regulation (decreases CBF and increases CBF pulsatility). The association between arterial stiffness and CBF pulsatility may, in part, explain the relationship between elevated blood pressure (BP) fluctuations and end-organ disease with aging. To understand the mechanisms by which large BP alterations influence cerebral blood flow regulation in both young and old, we examined the effects of age on central and cerebral blood flow regulation following an acute hypertensive stimulus [resistance-exercise (RE)]. Measurements were obtained pre and immediately, 5, and 30 min post-RE in young (n = 35) and older (n = 26) adults. Measurements included cerebral blood velocity (CBv), CBv pulsatility, central pulse-wave velocity (PWV), beta-stiffness index (β), and carotid blood flow pulsatility. Central hemodynamics and BP were continuously recorded. Mean CBv increased immediately post-RE only in the young and decreased below baseline at 5 min post-RE in both groups (interaction, P ≺ 0.05). Older adults had a greater increase in CBv pulsatility immediately post-RE compared with the young (interaction, P ≺ 0.05). Mean BP was higher and carotid pulsatility was lower in the older group and increased immediately post-RE in both groups (P ≺ 0.05). PWV increased immediately post-RE (P ≺ 0.05). There were no changes in β. In conclusion, with aging, greater central arterial stiffness leads to a greater transmission of pulsatile blood velocity from the systemic circulation to the cerebral circulation following an acute hypertensive stress.
AB - Aging increases arterial stiffness, which has a negative impact on cerebral blood flow (CBF) regulation (decreases CBF and increases CBF pulsatility). The association between arterial stiffness and CBF pulsatility may, in part, explain the relationship between elevated blood pressure (BP) fluctuations and end-organ disease with aging. To understand the mechanisms by which large BP alterations influence cerebral blood flow regulation in both young and old, we examined the effects of age on central and cerebral blood flow regulation following an acute hypertensive stimulus [resistance-exercise (RE)]. Measurements were obtained pre and immediately, 5, and 30 min post-RE in young (n = 35) and older (n = 26) adults. Measurements included cerebral blood velocity (CBv), CBv pulsatility, central pulse-wave velocity (PWV), beta-stiffness index (β), and carotid blood flow pulsatility. Central hemodynamics and BP were continuously recorded. Mean CBv increased immediately post-RE only in the young and decreased below baseline at 5 min post-RE in both groups (interaction, P ≺ 0.05). Older adults had a greater increase in CBv pulsatility immediately post-RE compared with the young (interaction, P ≺ 0.05). Mean BP was higher and carotid pulsatility was lower in the older group and increased immediately post-RE in both groups (P ≺ 0.05). PWV increased immediately post-RE (P ≺ 0.05). There were no changes in β. In conclusion, with aging, greater central arterial stiffness leads to a greater transmission of pulsatile blood velocity from the systemic circulation to the cerebral circulation following an acute hypertensive stress.
KW - Age
KW - Arterial blood pressure
KW - Arterial stiffness
KW - Cerebral blood flow
KW - Cerebral pulsatility
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U2 - 10.1152/japplphysiol.00137.2019
DO - 10.1152/japplphysiol.00137.2019
M3 - Article
C2 - 32240012
AN - SCOPUS:85084167769
SN - 8750-7587
VL - 128
SP - 1186
EP - 1195
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 5
ER -