Adsorption of the PtII anticancer drug carboplatin by mesoporous silica

Anthony J. Di Pasqua, Silvia Wallner, Deborah J. Kerwood, James C. Dabrowiak

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

MCM-41, a mesoporous silica nanomaterial with a high surface area for adsorption of small molecules, is a potential new type of delivery vehicle for therapeutic and diagnostic agents. In this report, we show that MCM-41 adsorbs the front-line anticancer drug carboplatin, [Pt(CBDCA-O,O′)(NH 3)2] (CBDCA=cyclobutane-1,1-dicarboxylate; 1), which is used to treat ovarian, lung, and other types of cancer. UV/Visible difference absorption spectroscopy shows that MCM-41 adsorbs 1.8±0.2% of its own weight of carboplatin after a 24 h exposure to 26.9 mm drug in H2O. The pseudo-first-order rate constant for adsorption of carboplatin by MCM-41, measured using [1H,15N] heteronuclear single quantum coherence (HSQC) NMR, and 15N-labeled carboplatin is k 1=2.92±2.17×10-6 s-1 at ca. 25°.

Original languageEnglish (US)
Pages (from-to)1343-1349
Number of pages7
JournalChemistry and Biodiversity
Volume6
Issue number9
DOIs
StatePublished - Sep 1 2009

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

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