TY - JOUR
T1 - Adsorption of the PtII anticancer drug carboplatin by mesoporous silica
AU - Di Pasqua, Anthony J.
AU - Wallner, Silvia
AU - Kerwood, Deborah J.
AU - Dabrowiak, James C.
PY - 2009/9
Y1 - 2009/9
N2 - MCM-41, a mesoporous silica nanomaterial with a high surface area for adsorption of small molecules, is a potential new type of delivery vehicle for therapeutic and diagnostic agents. In this report, we show that MCM-41 adsorbs the front-line anticancer drug carboplatin, [Pt(CBDCA-O,O′)(NH 3)2] (CBDCA=cyclobutane-1,1-dicarboxylate; 1), which is used to treat ovarian, lung, and other types of cancer. UV/Visible difference absorption spectroscopy shows that MCM-41 adsorbs 1.8±0.2% of its own weight of carboplatin after a 24 h exposure to 26.9 mm drug in H2O. The pseudo-first-order rate constant for adsorption of carboplatin by MCM-41, measured using [1H,15N] heteronuclear single quantum coherence (HSQC) NMR, and 15N-labeled carboplatin is k 1=2.92±2.17×10-6 s-1 at ca. 25°.
AB - MCM-41, a mesoporous silica nanomaterial with a high surface area for adsorption of small molecules, is a potential new type of delivery vehicle for therapeutic and diagnostic agents. In this report, we show that MCM-41 adsorbs the front-line anticancer drug carboplatin, [Pt(CBDCA-O,O′)(NH 3)2] (CBDCA=cyclobutane-1,1-dicarboxylate; 1), which is used to treat ovarian, lung, and other types of cancer. UV/Visible difference absorption spectroscopy shows that MCM-41 adsorbs 1.8±0.2% of its own weight of carboplatin after a 24 h exposure to 26.9 mm drug in H2O. The pseudo-first-order rate constant for adsorption of carboplatin by MCM-41, measured using [1H,15N] heteronuclear single quantum coherence (HSQC) NMR, and 15N-labeled carboplatin is k 1=2.92±2.17×10-6 s-1 at ca. 25°.
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U2 - 10.1002/cbdv.200900021
DO - 10.1002/cbdv.200900021
M3 - Article
C2 - 19774597
AN - SCOPUS:70349440990
SN - 1612-1872
VL - 6
SP - 1343
EP - 1349
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
IS - 9
ER -