ADHD, major depressive disorder, and simple phobias are prevalent psychiatric conditions in youth with velocardiofacial syndrome

Kevin M. Antshel, Wanda Fremont, Nancy J. Roizen, Robert Shprintzen, Anne Marie Higgins, Amit Dhamoon, Wendy R. Kates

Research output: Contribution to journalArticlepeer-review

128 Scopus citations

Abstract

Objective: To examine prevalence rates of psychopathology in children with velocardiofacial syndrome (VCFS). Method: One hundred fifty-four children ages 6 to 15 participated in our between-group design with three samples, 84 children with VCFS (37 girls, 47 boys), 32 sibling controls (18 girls, 14 boys), and 38 community controls (12 girls, 26 boys). The Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version and several other parent report measures were used to assess for psychopathology. Results: Compared to both control samples, children with VCFS had higher prevalence rates of major depressive disorder, attention-deficit/hyperactivity disorder, simple phobias, and enuresis. Additional findings from our analyses include (1) no gender differences in VCFS psychopathology prevalence rates, (2) children with VCFS who have comorbid psychopathology were rated by their parents as having less well-developed executive functions, and (3) across all three samples, the higher the IQ was, the higher the level of global functioning. Conclusions: These findings are consistent with previous research and suggest that major depressive disorder, attention-deficit/hyperactivity disorder, and simple phobias are salient features of the VCFS psychiatric phenotype.

Original languageEnglish (US)
Pages (from-to)596-603
Number of pages8
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume45
Issue number5
DOIs
StatePublished - May 2006

Keywords

  • Attention-deficit/hyperactivity disorder
  • Executive function
  • Major depressive disorder
  • Phobia
  • Velocardiofacial syndrome

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

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