Adaptive thermogenesis is intact in B6 and A/J mice studied at thermoneutrality

L. R. Deruisseau, A. D. Parsons, J. M. Overton

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


To investigate mechanisms of resistance to obesity, the physiologic responses to short-term moderate fat feeding were studied at ambient temperature (Ta) = 23°C and thermonuetrality (Ta = 30°C) in mice susceptible (B6) or resistant (A/J) to obesity. We hypothesized that A/J mice would exhibit greater adaptive thermogenic responses to consumption of moderate-fat diets, and that this response would be attenuated in thermoneutral conditions due to reduced activity of brown adipose tissue (BAT). B6 and A/J mice were adapted to either Ta = 23°C or Ta = 30°C, implanted with telemetry devices, housed in metabolic chambers for measurement of food intake, oxygen consumption (VO2), and heart rate (HR), and studied before and during 1 week of consuming a diet containing 32% of calories from fat. Access to 32% fat diet resulted in increased caloric intake in both strains, but caloric intake for A/J mice returned to baseline levels within 72 hours, while B6 mice remained hyperphagic. Both strains exhibited increased light-phase VO2 indicative of adaptive thermogenesis; however, there was no strain difference in light-phase VO2 during the 1-week feeding trial. Surprisingly, Ta had no effect on diet-induced thermogenesis in either mouse strain. Moderate high-fat feeding produced mild tachycardia that was similar in B6 and A/J mice and more clearly evident at thermonuetrality. We conclude that adaptive thermogenic responses are intact in both mouse strains studied at thermoneutrality, suggesting a minimal role for BAT in the initial metabolic response to hyperphagia. Furthermore, the results suggest that differences in control of caloric intake, rather than capacity for adaptive thermogenesis, may contribute to the relative susceptibility to obesity in A/J and B6 mice.

Original languageEnglish (US)
Pages (from-to)1417-1423
Number of pages7
JournalMetabolism: Clinical and Experimental
Issue number11
StatePublished - Nov 2004
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


Dive into the research topics of 'Adaptive thermogenesis is intact in B6 and A/J mice studied at thermoneutrality'. Together they form a unique fingerprint.

Cite this