Acute effect of high-intensity cycling exercise on carotid artery hemodynamic pulsatility

Matthew C. Babcock; Wesley K. Lefferts; William E. Hughes; Kimberly L. Fitzgerald; Briana K. Leyer; Jessica G. Redmond; Kevin S. Heffernan

doi:10.1007/s00421-014-3084-6

Acute effect of high-intensity cycling exercise on carotid artery hemodynamic pulsatility

Matthew C. Babcock, Wesley K. Lefferts, William E. Hughes, Kimberly L. Fitzgerald, Briana K. Leyer, Jessica G. Redmond, Kevin S. Heffernan

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Purpose: Investigate the effects of acute high-intensity exercise on common carotid artery (CCA) dimensions, stiffness, and wave intensity.

Methods: Fifty-five healthy men and women (22 ± 5 year; 24.5 ± 2.7 kg m−2) underwent 30 s of high-intensity cycling (HIC; Wingate anaerobic test). CCA diameter, stiffness [β-stiffness, Elastic Modulus (Ep)], pulsatility index (PI), forward wave intensities [due to LV contraction (W1) and LV suction (W2)], and reflected wave intensity [negative area (NA)] were assessed using a combination of Doppler ultrasound, wave intensity analysis, and applanation tonometry at baseline and immediately post-HIC.

Results: CCA β-stiffness, Ep, PI and pulse pressure increased significantly immediately post-HIC (p < 0.05). CCA diameter decreased acutely post-HIC (p < 0.05). There were also significant increases in W1 and NA and a significant decrease in W2 (p < 0.05). A significant correlation was found between change in W1 and PI (r = 0.438, p < 0.05), from rest to recovery as well as a significant inverse correlation between W2 and PI (r = −0.378, p < 0.05). Change in PI was not associated with change in CCA stiffness or NA (p > 0.05).

Conclusions: Acute HIC results in CCA constriction and increases in CCA stiffness along with increases in hemodynamic pulsatility. The increase in pulsatility may be due to a combination of increased forward wave intensity from increased LV contractility into a smaller vessel (i.e. impaired matching of diameter and flow) coupled with reduced LV suction.

Original language	English (US)
Pages (from-to)	1037-1045
Number of pages	9
Journal	European Journal of Applied Physiology
Volume	115
Issue number	5
DOIs	https://doi.org/10.1007/s00421-014-3084-6
State	Published - May 1 2015

Keywords

Arterial stiffness
Exercise
Hemodynamic pulsatility
Wave intensity analysis
Wave reflection

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Public Health, Environmental and Occupational Health
Physiology (medical)

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10.1007/s00421-014-3084-6

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@article{14795c6247f6449d99da78d2320bcdc2,

title = "Acute effect of high-intensity cycling exercise on carotid artery hemodynamic pulsatility",

abstract = "Purpose: Investigate the effects of acute high-intensity exercise on common carotid artery (CCA) dimensions, stiffness, and wave intensity.Methods: Fifty-five healthy men and women (22 ± 5 year; 24.5 ± 2.7 kg m−2) underwent 30 s of high-intensity cycling (HIC; Wingate anaerobic test). CCA diameter, stiffness [β-stiffness, Elastic Modulus (Ep)], pulsatility index (PI), forward wave intensities [due to LV contraction (W1) and LV suction (W2)], and reflected wave intensity [negative area (NA)] were assessed using a combination of Doppler ultrasound, wave intensity analysis, and applanation tonometry at baseline and immediately post-HIC.Results: CCA β-stiffness, Ep, PI and pulse pressure increased significantly immediately post-HIC (p < 0.05). CCA diameter decreased acutely post-HIC (p < 0.05). There were also significant increases in W1 and NA and a significant decrease in W2 (p < 0.05). A significant correlation was found between change in W1 and PI (r = 0.438, p < 0.05), from rest to recovery as well as a significant inverse correlation between W2 and PI (r = −0.378, p < 0.05). Change in PI was not associated with change in CCA stiffness or NA (p > 0.05).Conclusions: Acute HIC results in CCA constriction and increases in CCA stiffness along with increases in hemodynamic pulsatility. The increase in pulsatility may be due to a combination of increased forward wave intensity from increased LV contractility into a smaller vessel (i.e. impaired matching of diameter and flow) coupled with reduced LV suction.",

keywords = "Arterial stiffness, Exercise, Hemodynamic pulsatility, Wave intensity analysis, Wave reflection",

author = "Babcock, {Matthew C.} and Lefferts, {Wesley K.} and Hughes, {William E.} and Fitzgerald, {Kimberly L.} and Leyer, {Briana K.} and Redmond, {Jessica G.} and Heffernan, {Kevin S.}",

note = "Publisher Copyright: {\textcopyright} 2014, Springer-Verlag Berlin Heidelberg.",

year = "2015",

month = may,

day = "1",

doi = "10.1007/s00421-014-3084-6",

language = "English (US)",

volume = "115",

pages = "1037--1045",

journal = "European Journal of Applied Physiology",

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TY - JOUR

T1 - Acute effect of high-intensity cycling exercise on carotid artery hemodynamic pulsatility

AU - Babcock, Matthew C.

AU - Lefferts, Wesley K.

AU - Hughes, William E.

AU - Fitzgerald, Kimberly L.

AU - Leyer, Briana K.

AU - Redmond, Jessica G.

AU - Heffernan, Kevin S.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Purpose: Investigate the effects of acute high-intensity exercise on common carotid artery (CCA) dimensions, stiffness, and wave intensity.Methods: Fifty-five healthy men and women (22 ± 5 year; 24.5 ± 2.7 kg m−2) underwent 30 s of high-intensity cycling (HIC; Wingate anaerobic test). CCA diameter, stiffness [β-stiffness, Elastic Modulus (Ep)], pulsatility index (PI), forward wave intensities [due to LV contraction (W1) and LV suction (W2)], and reflected wave intensity [negative area (NA)] were assessed using a combination of Doppler ultrasound, wave intensity analysis, and applanation tonometry at baseline and immediately post-HIC.Results: CCA β-stiffness, Ep, PI and pulse pressure increased significantly immediately post-HIC (p < 0.05). CCA diameter decreased acutely post-HIC (p < 0.05). There were also significant increases in W1 and NA and a significant decrease in W2 (p < 0.05). A significant correlation was found between change in W1 and PI (r = 0.438, p < 0.05), from rest to recovery as well as a significant inverse correlation between W2 and PI (r = −0.378, p < 0.05). Change in PI was not associated with change in CCA stiffness or NA (p > 0.05).Conclusions: Acute HIC results in CCA constriction and increases in CCA stiffness along with increases in hemodynamic pulsatility. The increase in pulsatility may be due to a combination of increased forward wave intensity from increased LV contractility into a smaller vessel (i.e. impaired matching of diameter and flow) coupled with reduced LV suction.

AB - Purpose: Investigate the effects of acute high-intensity exercise on common carotid artery (CCA) dimensions, stiffness, and wave intensity.Methods: Fifty-five healthy men and women (22 ± 5 year; 24.5 ± 2.7 kg m−2) underwent 30 s of high-intensity cycling (HIC; Wingate anaerobic test). CCA diameter, stiffness [β-stiffness, Elastic Modulus (Ep)], pulsatility index (PI), forward wave intensities [due to LV contraction (W1) and LV suction (W2)], and reflected wave intensity [negative area (NA)] were assessed using a combination of Doppler ultrasound, wave intensity analysis, and applanation tonometry at baseline and immediately post-HIC.Results: CCA β-stiffness, Ep, PI and pulse pressure increased significantly immediately post-HIC (p < 0.05). CCA diameter decreased acutely post-HIC (p < 0.05). There were also significant increases in W1 and NA and a significant decrease in W2 (p < 0.05). A significant correlation was found between change in W1 and PI (r = 0.438, p < 0.05), from rest to recovery as well as a significant inverse correlation between W2 and PI (r = −0.378, p < 0.05). Change in PI was not associated with change in CCA stiffness or NA (p > 0.05).Conclusions: Acute HIC results in CCA constriction and increases in CCA stiffness along with increases in hemodynamic pulsatility. The increase in pulsatility may be due to a combination of increased forward wave intensity from increased LV contractility into a smaller vessel (i.e. impaired matching of diameter and flow) coupled with reduced LV suction.

KW - Arterial stiffness

KW - Exercise

KW - Hemodynamic pulsatility

KW - Wave intensity analysis

KW - Wave reflection

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U2 - 10.1007/s00421-014-3084-6

DO - 10.1007/s00421-014-3084-6

M3 - Article

C2 - 25543325

AN - SCOPUS:84928329196

SN - 1439-6319

VL - 115

SP - 1037

EP - 1045

JO - European Journal of Applied Physiology

JF - European Journal of Applied Physiology

IS - 5

ER -

Acute effect of high-intensity cycling exercise on carotid artery hemodynamic pulsatility

Abstract

Keywords

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