Activity of trimethoprim (TMP), sulphamethoxazole (SMX) and the combination against bacteroides fragilis group isolates

Gary L. Jackson-york; Brooks B. Gump; Dieter W. Gump

doi:10.1093/jac/12.5.515

Activity of trimethoprim (TMP), sulphamethoxazole (SMX) and the combination against bacteroides fragilis group isolates

Gary L. Jackson-york, Brooks B. Gump, Dieter W. Gump

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The in-vitro efficacy of trimethoprim/sulphamethoxazole (TMP/SMX) was tested against 59 isolates belonging to the Bacteroides fragilis group of bacteria and was shown to be dependent upon the inoculum size. With an inoculum of 3 × 10⁵ colony forming units (cfu), 98% of these isolates were susceptible to the combination, whereas with a higher inoculum of 10⁶ cfu, 88% were susceptible. None of the isolates were susceptible to less than 2 mg/l of TMP, whereas 57 (97%) were susceptible to SMX at the lower inoculum and 21 (36%) at the higher inoculum. These data indicate that TMP/SMX has moderate activity against organisms of the Bact. fragilis group when tested at an inoculum of 10⁶ cfu.

Original language	English (US)
Pages (from-to)	515-518
Number of pages	4
Journal	Journal of Antimicrobial Chemotherapy
Volume	12
Issue number	5
DOIs	https://doi.org/10.1093/jac/12.5.515
State	Published - Nov 1 1983
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

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10.1093/jac/12.5.515

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title = "Activity of trimethoprim (TMP), sulphamethoxazole (SMX) and the combination against bacteroides fragilis group isolates",

abstract = "The in-vitro efficacy of trimethoprim/sulphamethoxazole (TMP/SMX) was tested against 59 isolates belonging to the Bacteroides fragilis group of bacteria and was shown to be dependent upon the inoculum size. With an inoculum of 3 × 105 colony forming units (cfu), 98% of these isolates were susceptible to the combination, whereas with a higher inoculum of 106 cfu, 88% were susceptible. None of the isolates were susceptible to less than 2 mg/l of TMP, whereas 57 (97%) were susceptible to SMX at the lower inoculum and 21 (36%) at the higher inoculum. These data indicate that TMP/SMX has moderate activity against organisms of the Bact. fragilis group when tested at an inoculum of 106 cfu.",

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