Abstract
The in-vitro efficacy of trimethoprim/sulphamethoxazole (TMP/SMX) was tested against 59 isolates belonging to the Bacteroides fragilis group of bacteria and was shown to be dependent upon the inoculum size. With an inoculum of 3 × 105 colony forming units (cfu), 98% of these isolates were susceptible to the combination, whereas with a higher inoculum of 106 cfu, 88% were susceptible. None of the isolates were susceptible to less than 2 mg/l of TMP, whereas 57 (97%) were susceptible to SMX at the lower inoculum and 21 (36%) at the higher inoculum. These data indicate that TMP/SMX has moderate activity against organisms of the Bact. fragilis group when tested at an inoculum of 106 cfu.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 515-518 |
| Number of pages | 4 |
| Journal | Journal of Antimicrobial Chemotherapy |
| Volume | 12 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 1 1983 |
| Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology
- Microbiology (medical)
- Infectious Diseases
- Pharmacology (medical)
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Cite this
Jackson-york, G. L., Gump, B. B., & Gump, D. W. (1983). Activity of trimethoprim (TMP), sulphamethoxazole (SMX) and the combination against bacteroides fragilis group isolates. Journal of Antimicrobial Chemotherapy, 12(5), 515-518. https://doi.org/10.1093/jac/12.5.515