Active surface wrinkling influences cell migration behavior and control

M. E. Brasch, J. H. Henderson, M. L. Manning, N. Deakin, C. E. Turner

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Dynamic reorganization of a cell's local microenvironment has been shown to critically alter migration, adhesion, and morphological behaviors in vivo during development, wound healing, and disease. While static microenvironments with patterned topographies, stiffness variations, or chemical gradients have been used to characterize cell responses in vitro, they are incapable of capturing the dynamic functionality of extracellular matrix naturally seen in the body. Here, we use a thermally responsive class of materials, shape memory polymers (SMPs), to dynamically manipulate the topographical environment cells experience. By providing physical manipulation of the microenvironment, we demonstrate the ability to control cell migratory behavior in response to a dynamic topographical change provided by SMPs.

Original languageEnglish (US)
Title of host publication2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479983605
DOIs
StatePublished - Jun 2 2015
Event2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 - Troy, United States
Duration: Apr 17 2015Apr 19 2015

Publication series

Name2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015

Other

Other2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
CountryUnited States
CityTroy
Period4/17/154/19/15

ASJC Scopus subject areas

  • Biotechnology
  • Cancer Research
  • Cell Biology
  • Molecular Medicine
  • Biomedical Engineering
  • Control and Systems Engineering

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    Brasch, M. E., Henderson, J. H., Manning, M. L., Deakin, N., & Turner, C. E. (2015). Active surface wrinkling influences cell migration behavior and control. In 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 [7117055] (2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NEBEC.2015.7117055