Active surface wrinkling influences cell migration behavior and control

M. E. Brasch; J. H. Henderson; M. L. Manning; N. Deakin; C. E. Turner

doi:10.1109/NEBEC.2015.7117055

Active surface wrinkling influences cell migration behavior and control

M. E. Brasch, J. H. Henderson, M. L. Manning, N. Deakin, C. E. Turner

Research output: Chapter in Book/Entry/Poem › Conference contribution

Abstract

Dynamic reorganization of a cell's local microenvironment has been shown to critically alter migration, adhesion, and morphological behaviors in vivo during development, wound healing, and disease. While static microenvironments with patterned topographies, stiffness variations, or chemical gradients have been used to characterize cell responses in vitro, they are incapable of capturing the dynamic functionality of extracellular matrix naturally seen in the body. Here, we use a thermally responsive class of materials, shape memory polymers (SMPs), to dynamically manipulate the topographical environment cells experience. By providing physical manipulation of the microenvironment, we demonstrate the ability to control cell migratory behavior in response to a dynamic topographical change provided by SMPs.

Original language	English (US)
Title of host publication	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781479983605
DOIs	https://doi.org/10.1109/NEBEC.2015.7117055
State	Published - Jun 2 2015
Event	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 - Troy, United States Duration: Apr 17 2015 → Apr 19 2015

Publication series

Name	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015

Other

Other	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
Country/Territory	United States
City	Troy
Period	4/17/15 → 4/19/15

ASJC Scopus subject areas

Biotechnology
Cancer Research
Cell Biology
Molecular Medicine
Biomedical Engineering
Control and Systems Engineering

Access to Document

10.1109/NEBEC.2015.7117055

Cite this

Brasch, M. E., Henderson, J. H., Manning, M. L., Deakin, N., & Turner, C. E. (2015). Active surface wrinkling influences cell migration behavior and control. In 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 Article 7117055 (2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NEBEC.2015.7117055

Active surface wrinkling influences cell migration behavior and control. / Brasch, M. E.; Henderson, J. H.; Manning, M. L. et al.
2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015. Institute of Electrical and Electronics Engineers Inc., 2015. 7117055 (2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015).

Research output: Chapter in Book/Entry/Poem › Conference contribution

Brasch, ME, Henderson, JH , Manning, ML, Deakin, N & Turner, CE 2015, Active surface wrinkling influences cell migration behavior and control. in 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015., 7117055, 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015, Institute of Electrical and Electronics Engineers Inc., 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015, Troy, United States, 4/17/15. https://doi.org/10.1109/NEBEC.2015.7117055

Brasch ME, Henderson JH , Manning ML, Deakin N, Turner CE. Active surface wrinkling influences cell migration behavior and control. In 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015. Institute of Electrical and Electronics Engineers Inc. 2015. 7117055. (2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015). doi: 10.1109/NEBEC.2015.7117055

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Active surface wrinkling influences cell migration behavior and control

Abstract

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