Active elastic dimers: Cells moving on rigid tracks

J. H. Lopez, Moumita Das, Jennifer M Schwarz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Experiments suggest that the migration of some cells in the three-dimensional extracellular matrix bears strong resemblance to one-dimensional cell migration. Motivated by this observation, we construct and study a minimal one-dimensional model cell made of two beads and an active spring moving along a rigid track. The active spring models the stress fibers with their myosin-driven contractility and α-actinin-driven extendability, while the friction coefficients of the two beads describe the catch and slip-bond behaviors of the integrins in focal adhesions. In the absence of active noise, net motion arises from an interplay between active contractility (and passive extendability) of the stress fibers and an asymmetry between the front and back of the cell due to catch-bond behavior of integrins at the front of the cell and slip-bond behavior of integrins at the back. We obtain reasonable cell speeds with independently estimated parameters. We also study the effects of hysteresis in the active spring, due to catch-bond behavior and the dynamics of cross linking, and the addition of active noise on the motion of the cell. Our model highlights the role of α-actinin in three-dimensional cell motility and does not require Arp2/3 actin filament nucleation for net motion.

Original languageEnglish (US)
Article number032707
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume90
Issue number3
DOIs
StatePublished - Sep 18 2014

Fingerprint

Dimer
dimers
Integrin
Cell
cells
Contractility
Extendability
Slip
Motion
Fiber
beads
Cell Motility
Cell Migration
Three-dimensional
slip
Myosin
Actin
Minimal Model
Friction Coefficient
Filament

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Statistical and Nonlinear Physics
  • Statistics and Probability

Cite this

Active elastic dimers : Cells moving on rigid tracks. / Lopez, J. H.; Das, Moumita; Schwarz, Jennifer M.

In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, Vol. 90, No. 3, 032707, 18.09.2014.

Research output: Contribution to journalArticle

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