TY - JOUR
T1 - Absorption studies on aminoglycoside binding to the packaging region of human immunodeficiency virus type-1
AU - Sullivan, Julie M.
AU - Goodisman, Jerry
AU - Dabrowiak, James C.
N1 - Funding Information:
We thank NSF-REU (CHE 9987838) for financial support to J.M.S. We are grateful to M. P. McPike, for technical assistance and samples of the 176-mer RNA and we also wish to thank Y. Tor (U. C. San Diego) for the neomycin analogues and R. H. Shafer (U. C. San Francisco) for helpful discussions. Special thanks to Andrew Paoletti for sharing the results of electrophoresis experiments on a 154-mer RNA.
PY - 2002/2/25
Y1 - 2002/2/25
N2 - The binding of paromomycin, neomycin B, and three analogues of neomycin to a 176-mer RNA from the packaging region of HIV-1 (LAI) has been studied using UV absorption spectroscopy at wavelengths between 200 and 300 nm. From plots of absorption as a function of drug concentration, values of binding constants for these drugs on RNA were determined.
AB - The binding of paromomycin, neomycin B, and three analogues of neomycin to a 176-mer RNA from the packaging region of HIV-1 (LAI) has been studied using UV absorption spectroscopy at wavelengths between 200 and 300 nm. From plots of absorption as a function of drug concentration, values of binding constants for these drugs on RNA were determined.
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U2 - 10.1016/S0960-894X(01)00823-X
DO - 10.1016/S0960-894X(01)00823-X
M3 - Article
C2 - 11844684
AN - SCOPUS:0037169986
SN - 0960-894X
VL - 12
SP - 615
EP - 618
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 4
ER -