Absorption studies on aminoglycoside binding to the packaging region of human immunodeficiency virus type-1

Julie M. Sullivan, Jerry Goodisman, James C. Dabrowiak

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The binding of paromomycin, neomycin B, and three analogues of neomycin to a 176-mer RNA from the packaging region of HIV-1 (LAI) has been studied using UV absorption spectroscopy at wavelengths between 200 and 300 nm. From plots of absorption as a function of drug concentration, values of binding constants for these drugs on RNA were determined.

Original languageEnglish (US)
Pages (from-to)615-618
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number4
DOIs
StatePublished - Feb 25 2002

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Aminoglycosides
Product Packaging
Viruses
HIV-1
Packaging
Framycetin
Paromomycin
RNA
Neomycin
Ultraviolet spectroscopy
Absorption spectroscopy
Pharmaceutical Preparations
Spectrum Analysis
Wavelength

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Absorption studies on aminoglycoside binding to the packaging region of human immunodeficiency virus type-1. / Sullivan, Julie M.; Goodisman, Jerry; Dabrowiak, James C.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 12, No. 4, 25.02.2002, p. 615-618.

Research output: Contribution to journalArticle

Sullivan, Julie M. ; Goodisman, Jerry ; Dabrowiak, James C. / Absorption studies on aminoglycoside binding to the packaging region of human immunodeficiency virus type-1. In: Bioorganic and Medicinal Chemistry Letters. 2002 ; Vol. 12, No. 4. pp. 615-618.
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