Absorption studies on aminoglycoside binding to the packaging region of human immunodeficiency virus type-1

Julie M. Sullivan, Jerry Goodisman, James C. Dabrowiak

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The binding of paromomycin, neomycin B, and three analogues of neomycin to a 176-mer RNA from the packaging region of HIV-1 (LAI) has been studied using UV absorption spectroscopy at wavelengths between 200 and 300 nm. From plots of absorption as a function of drug concentration, values of binding constants for these drugs on RNA were determined.

Original languageEnglish (US)
Pages (from-to)615-618
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number4
DOIs
StatePublished - Feb 25 2002

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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