TY - JOUR
T1 - Absorption and Circular Dichroism Studies of a Gold (I)-DNA Complex
AU - Blank, C. E.
AU - Dabrowiak, J. C.
PY - 1984/5
Y1 - 1984/5
N2 - The DNA binding properties of the Au(I)-containing antiarthritic drug Ridaura and related Au(I) complexes have been investigated. Absorption and circular dichroism spectroscopy show that if the gold ion possesses an easily displaced ligand,e.g.,Cl-or Br-,Au(I) is capable of interacting, in a nondenaturing fashion, with calf thymus DNA. Absorption studies with the four DNA nucleosides suggest that guanine and cytosine bases are important in the Au(I)DNA interaction.
AB - The DNA binding properties of the Au(I)-containing antiarthritic drug Ridaura and related Au(I) complexes have been investigated. Absorption and circular dichroism spectroscopy show that if the gold ion possesses an easily displaced ligand,e.g.,Cl-or Br-,Au(I) is capable of interacting, in a nondenaturing fashion, with calf thymus DNA. Absorption studies with the four DNA nucleosides suggest that guanine and cytosine bases are important in the Au(I)DNA interaction.
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U2 - 10.1016/0162-0134(84)85036-9
DO - 10.1016/0162-0134(84)85036-9
M3 - Article
C2 - 6547163
AN - SCOPUS:0021243001
SN - 0162-0134
VL - 21
SP - 21
EP - 29
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
IS - 1
ER -