Absorption and Circular Dichroism Studies of a Gold (I)-DNA Complex

C. E. Blank, J. C. Dabrowiak

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

The DNA binding properties of the Au(I)-containing antiarthritic drug Ridaura and related Au(I) complexes have been investigated. Absorption and circular dichroism spectroscopy show that if the gold ion possesses an easily displaced ligand,e.g.,Cl-or Br-,Au(I) is capable of interacting, in a nondenaturing fashion, with calf thymus DNA. Absorption studies with the four DNA nucleosides suggest that guanine and cytosine bases are important in the Au(I)DNA interaction.

Original languageEnglish (US)
Pages (from-to)21-29
Number of pages9
JournalJournal of Inorganic Biochemistry
Volume21
Issue number1
DOIs
StatePublished - May 1984

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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