Absorption and Circular Dichroism Studies of a Gold (I)-DNA Complex

C. E. Blank, J. C. Dabrowiak

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The DNA binding properties of the Au(I)-containing antiarthritic drug Ridaura and related Au(I) complexes have been investigated. Absorption and circular dichroism spectroscopy show that if the gold ion possesses an easily displaced ligand,e.g.,Cl-or Br-,Au(I) is capable of interacting, in a nondenaturing fashion, with calf thymus DNA. Absorption studies with the four DNA nucleosides suggest that guanine and cytosine bases are important in the Au(I)DNA interaction.

Original languageEnglish (US)
Pages (from-to)21-29
Number of pages9
JournalJournal of Inorganic Biochemistry
Volume21
Issue number1
DOIs
StatePublished - 1984

Fingerprint

Circular Dichroism
Gold
DNA
Auranofin
Circular dichroism spectroscopy
Cytosine
Guanine
Nucleosides
Spectrum Analysis
Ions
Ligands
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Absorption and Circular Dichroism Studies of a Gold (I)-DNA Complex. / Blank, C. E.; Dabrowiak, J. C.

In: Journal of Inorganic Biochemistry, Vol. 21, No. 1, 1984, p. 21-29.

Research output: Contribution to journalArticle

Blank, C. E. ; Dabrowiak, J. C. / Absorption and Circular Dichroism Studies of a Gold (I)-DNA Complex. In: Journal of Inorganic Biochemistry. 1984 ; Vol. 21, No. 1. pp. 21-29.
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