TY - JOUR
T1 - Abnormalities in brain white matter in adolescents with 22q11.2 deletion syndrome and psychotic symptoms
AU - Kikinis, Zora
AU - Cho, Kang Ik K.
AU - Coman, Ioana L.
AU - Radoeva, Petya D.
AU - Bouix, Sylvain
AU - Tang, Yingying
AU - Eckbo, Ryan
AU - Makris, Nikos
AU - Kwon, Jun Soo
AU - Kubicki, Marek
AU - Antshel, Kevin M.
AU - Fremont, Wanda
AU - Shenton, Martha E.
AU - Kates, Wendy R.
N1 - Funding Information:
Acknowledgment This work was supported by grants from the National Institute of Mental Health R01MH064824 (to WRK), R21MH106793 (to ZK), R01 MH102377 (to MK), VA Merit Award (to MES).
Funding Information:
This work was supported by grants from the National Institute of Mental Health R01MH064824 (to WRK), R21MH106793 (to ZK), R01 MH102377 (to MK), VA Merit Award (to MES). Martha E. Shenton and Wendy R. Kates Equal Last Authorship Endnote : A preliminary analysis of this study has been included in an abstract for the 2014 meeting of the International Society for Developmental Neuroscience.
Publisher Copyright:
© 2016, Springer Science+Business Media New York.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Background: 22q11.2 Deletion Syndrome (22q11DS) is considered to be a promising cohort to explore biomarkers of schizophrenia risk based on a 30 % probability of developing schizophrenia in adulthood. In this study, we investigated abnormalities in the microstructure of white matter in adolescents with 22q11DS and their specificity to prodromal symptoms of schizophrenia. Methods: Diffusion Magnetic Resonance Imaging (dMRI) data were acquired from 50 subjects with 22q11DS (9 with and 41 without prodromal psychotic symptoms), and 47 matched healthy controls (mean age 18 +/−2 years). DMRI measures, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were calculated and compared between groups using the Tract Based Spatial Statistics (TBSS) method. Additionally, correlations between dMRI measures and scores on positive symptoms were performed. Results: Reductions in MD, AD and RD (but not FA) were found in the corpus callosum (CC), left and right superior longitudinal fasciculus (SLF), and left and right corona radiata in the entire 22q11DS group. In addition, the 22q11DS subgroup with prodromal symptoms showed reductions in AD and MD, but no changes in RD when compared to the non-prodromal subgroup, in CC, right SLF, right corona radiata and right internal capsule. Finally, AD values in these tracts correlated with the scores on the psychosis subscale. Conclusion: Microstructural abnormalities in brain white matter are present in adolescent subjects with prodromal psychotic symptoms.
AB - Background: 22q11.2 Deletion Syndrome (22q11DS) is considered to be a promising cohort to explore biomarkers of schizophrenia risk based on a 30 % probability of developing schizophrenia in adulthood. In this study, we investigated abnormalities in the microstructure of white matter in adolescents with 22q11DS and their specificity to prodromal symptoms of schizophrenia. Methods: Diffusion Magnetic Resonance Imaging (dMRI) data were acquired from 50 subjects with 22q11DS (9 with and 41 without prodromal psychotic symptoms), and 47 matched healthy controls (mean age 18 +/−2 years). DMRI measures, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were calculated and compared between groups using the Tract Based Spatial Statistics (TBSS) method. Additionally, correlations between dMRI measures and scores on positive symptoms were performed. Results: Reductions in MD, AD and RD (but not FA) were found in the corpus callosum (CC), left and right superior longitudinal fasciculus (SLF), and left and right corona radiata in the entire 22q11DS group. In addition, the 22q11DS subgroup with prodromal symptoms showed reductions in AD and MD, but no changes in RD when compared to the non-prodromal subgroup, in CC, right SLF, right corona radiata and right internal capsule. Finally, AD values in these tracts correlated with the scores on the psychosis subscale. Conclusion: Microstructural abnormalities in brain white matter are present in adolescent subjects with prodromal psychotic symptoms.
KW - 22q11.2 deletion syndrome (22q11DS)
KW - Brain white matter
KW - Diffusion tensor magnetic resonance imaging (dMRI)
KW - Tract-based spatial statistics (TBSS)
KW - Velo-cardio-facial syndrome (VCFS)
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U2 - 10.1007/s11682-016-9602-x
DO - 10.1007/s11682-016-9602-x
M3 - Article
C2 - 27730479
AN - SCOPUS:85042000998
SN - 1931-7557
VL - 11
SP - 1353
EP - 1364
JO - Brain Imaging and Behavior
JF - Brain Imaging and Behavior
IS - 5
ER -