A tubular biomaterial construct exhibiting a negative poisson's ratio

Jin Woo Lee, Pranav Soman, Jeong Hun Park, Shaochen Chen, Dong Woo Cho

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Developing functional small-diameter vascular grafts is an important objective in tissue engineering research. In this study, we address the problem of compliance mismatch by designing and developing a 3D tubular construct that has a negative Poisson's ratio vxy (NPR). NPR constructs have the unique ability to expand transversely when pulled axially, thereby resulting in a highly-compliant tubular construct. In this work, we used projection stereolithography to 3D-print a planar NPR sheet composed of photosensitive poly(ethylene) glycol diacrylate biomaterial. We used a step-lithography exposure and a stitch process to scale up the projection printing process, and used the cut-missing rib unit design to develop a centimeter-scale NPR sheet, which was rolled up to form a tubular construct. The constructs had Poisson's ratios of -0.6 ≤ vxy ≤ -0.1. The NPR construct also supports higher cellular adhesion than does the construct that has positive vxy. Our NPR design offers a significant advance in the development of highly-compliant vascular grafts.

Original languageEnglish (US)
Article numbere0155681
JournalPLoS One
Volume11
Issue number5
DOIs
StatePublished - May 1 2016

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ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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