A Theory of Phase Transitions and Phase Diagrams for One- and Two- Component Phospholipid Bilayers

Russell E. Jacobs, Bruce S. Hudson, Hans C. Andersen

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Abstract

A statistical mechanical partition function for phospholipid bilayers is constructed to obtain a theoretical description of the chain melting phase transition in lipid bilayer membranes and of the phase diagrams for two-component bilayers. In addition to providing an accurate representation of the transition temperatures and enthalpies of one-component bilayers composed of 1,2-diacylphosphatidylcholines, the theory can also account for the shapes of the phase diagrams observed for bilayers which are binary mixtures of these compounds with two different hydrocarbon chain lengths.

Original languageEnglish (US)
Pages (from-to)4349-4359
Number of pages11
JournalBiochemistry
Volume16
Issue number20
DOIs
StatePublished - Oct 1 1977

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ASJC Scopus subject areas

  • Biochemistry

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