A systematic appraisal of ventricular-aortic load in African American men

Kevin S. Heffernan, Bo Fernhall

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background: We examined several measures of ventricular-vascular load as they relate to ECG-derived measures of left ventricular (LV) morphology in a cross-section of 19 young African American and 19 white men. Methods: Measures of steady and pulsatile LV load derived from aortic blood pressure waveforms included: aortic characteristic impedance (Zc), effective arterial elastance (Ea), arterial compliance, aortic reservoir function, aortic wave reflection (AIx), and total peripheral resistance (TPR). Also derived from the pressure waveform were the rate pressure product (RPP), tension-time index (TTI), diastolic pressure-time index (DPTI), and the subendocardial viability ratio (SEVR). ECG was used to measure R-wave area, R-wave amplitude, and QRS duration as crude proxies of LV morphology. Results: African American men had greater Ea, AIx, TPR and reduced aortic compliance compared with white men (all p < 0.05). There was a positive association between Ea, Zc, TPR and LV morphology (p < 0.05). There was an inverse association between arterial compliance and LV morphology (p < 0.05). AIx was not associated with LV morphology. There were no racial differences in aortic reservoir function, RPP, TTI, DPTI, or SEVR. Aortic reservoir function was positively associated with DPTI and SEVR (p < 0.05) and inversely associated with RPP (p < 0.05). Conclusions: In young African American men, LV morphology is influenced by LV load stemming from aortic stiffness and vascular resistance more-so than augmented pressure from wave reflections. Aortic reservoir function is preserved in young African American men, balancing myocardial oxygen supply and demand in the presence of altered vascular-ventricular coupling and LV remodeling.

Original languageEnglish (US)
Pages (from-to)65-72
Number of pages8
JournalArtery Research
Volume3
Issue number2
DOIs
StatePublished - Jun 1 2009
Externally publishedYes

Keywords

  • Arterial stiffness
  • Hemodynamic
  • Left ventricle
  • Wave reflection

ASJC Scopus subject areas

  • Anatomy
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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