A simple method for kinetic control of DNA-induced nanoparticle assembly

Mathew M. Maye, Dmytro Nykypanchuk, Daniel Van Der Lelie, Oleg Gang

Research output: Contribution to journalArticlepeer-review

105 Scopus citations


A regulation of the kinetic behavior in DNA-based nanosystems is required for emerging applications in sensing, nanodevice assembling, and gene delivery. Here we describe a broadly applicable method for controlling the kinetics of DNA-mediated nanoparticle self-assembly by tailoring the DNA-capping between single-stranded and partially rigid double-stranded designs. An effect of enhanced assembly kinetics was facilitated by the added rigidity which reduced chain entropy while extending crucial linker segments away from the nanoparticle interface where they are known to coordinate.

Original languageEnglish (US)
Pages (from-to)14020-14021
Number of pages2
JournalJournal of the American Chemical Society
Issue number43
StatePublished - Nov 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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