A simple method for kinetic control of DNA-induced nanoparticle assembly

Mathew M. Maye; Dmytro Nykypanchuk; Daniel Van Der Lelie; Oleg Gang

doi:10.1021/ja0654229

A simple method for kinetic control of DNA-induced nanoparticle assembly

Mathew M. Maye, Dmytro Nykypanchuk, Daniel Van Der Lelie, Oleg Gang

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

A regulation of the kinetic behavior in DNA-based nanosystems is required for emerging applications in sensing, nanodevice assembling, and gene delivery. Here we describe a broadly applicable method for controlling the kinetics of DNA-mediated nanoparticle self-assembly by tailoring the DNA-capping between single-stranded and partially rigid double-stranded designs. An effect of enhanced assembly kinetics was facilitated by the added rigidity which reduced chain entropy while extending crucial linker segments away from the nanoparticle interface where they are known to coordinate.

Original language	English (US)
Pages (from-to)	14020-14021
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	128
Issue number	43
DOIs	https://doi.org/10.1021/ja0654229
State	Published - Nov 1 2006
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja0654229

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AB - A regulation of the kinetic behavior in DNA-based nanosystems is required for emerging applications in sensing, nanodevice assembling, and gene delivery. Here we describe a broadly applicable method for controlling the kinetics of DNA-mediated nanoparticle self-assembly by tailoring the DNA-capping between single-stranded and partially rigid double-stranded designs. An effect of enhanced assembly kinetics was facilitated by the added rigidity which reduced chain entropy while extending crucial linker segments away from the nanoparticle interface where they are known to coordinate.

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A simple method for kinetic control of DNA-induced nanoparticle assembly

Abstract

ASJC Scopus subject areas

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