A roadmap for research in post-stroke fatigue: Consensus-based core recommendations from the third Stroke Recovery and Rehabilitation Roundtable

Coralie English, Dawn B. Simpson, Sandra A. Billinger, Leonid Churilov, Kirsten G. Coupland, Avril Drummond, Annapoorna Kuppuswamy, Mansur A. Kutlubaev, Anners Lerdal, Amreen Mahmood, G. Lorimer Moseley, Quentin J. Pittman, Ellyn A. Riley, Brad A. Sutherland, Connie H.Y. Wong, Dale Corbett, Gillian Mead

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Rationale: Fatigue affects almost half of all people living with stroke. Stroke survivors rank understanding fatigue and how to reduce it as one of the highest research priorities. Methods: We convened an interdisciplinary, international group of clinical and pre-clinical researchers and lived experience experts. We identified four priority areas: (1) best measurement tools for research, (2) clinical identification of fatigue and potentially modifiable causes, (3) promising interventions and recommendations for future trials, and (4) possible biological mechanisms of fatigue. Cross-cutting themes were aphasia and the voice of people with lived experience. Working parties were formed and structured consensus building processes were followed. Results: We present 20 recommendations covering outcome measures for research, development, and testing of new interventions and priority areas for future research on the biology of post-stroke fatigue. We developed and recommend the use of the Stroke Fatigue Clinical Assessment Tool. Conclusions: By synthesizing current knowledge in post-stroke fatigue across clinical and pre-clinical fields, our work provides a roadmap for future research into post-stroke fatigue.

Original languageEnglish (US)
Pages (from-to)133-144
Number of pages12
JournalInternational Journal of Stroke
Volume19
Issue number2
DOIs
StatePublished - Feb 2024

Keywords

  • Stroke
  • consensus
  • fatigue
  • measurement
  • mechanisms
  • recovery
  • rehabilitation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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