A novel high-viscosity, two-solution acrylic bone cement: Effect of chemical composition on properties

Julie M. Hasenwinkel, Eugene P. Lautenschlager, Richard L. Wixson, Jeremy L. Gilbert

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Solutions of poly(methyl methacrylate) (PMMA) powder predissolved in methyl methacrylate (MMA) have been developed as an alternative to current powder/liquid bone cements. They utilize the same addition polymerization chemistry as commercial cements, but in mixing and delivering via a closed system, porosity is eliminated and the dependence of material properties on the surgical technique is decreased. Twelve different sets of compositions were prepared, with two solutions of constant polymer-to-monomer ratio (80 g of PMMA/100 mL of MMA) and all combinations of four benzoyl peroxide (BPO) initiator levels added to the first solution and three N,N-dimethyl-p-toluidine (DMPT) activator levels added to the second. These compositions were tested, along with Simplex-P bone cement, for effects of BPO and DMPT concentrations on polymerization exotherm, setting time, flexural strength, modulus, and maximum strain. The results show that each of these dependent variables was affected significantly by the individual concentrations of BPO and DMPT and their interactions. The flexural strength, modulus, and polymerization exotherm reached their maximums at about a 1:1 molar ratio of BPO to DMPT. Most compositions had exotherms, setting times, and maximum strains within the range of commercial cements and flexural strengths and moduli up to 54 and 43% higher than Simplex-P, respectively.

Original languageEnglish (US)
Pages (from-to)36-45
Number of pages10
JournalJournal of Biomedical Materials Research
Issue number1
StatePublished - 1999


  • Bone cement
  • Mechanical properties
  • Poly(methyl methacrylate) (PMMA)
  • Setting characteristics

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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