A new chiral titanium species for the ring opening reactions of meso epoxides

Alecia W. Eppley, Nancy I. Totah

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The synthesis of a new chiral ligand 1 based on the conformationally defined 1,7-dioxaspiro[5.5]undecane ring system is reported. Generation of the corresponding ligand 1-Ti(OiPr)4 complex as a catalyst and its use in the enantioselective ring opening reaction of cyclohexene oxide with TMSN3 is described.

Original languageEnglish (US)
Pages (from-to)16545-16552
Number of pages8
JournalTetrahedron
Volume53
Issue number48
DOIs
StatePublished - Dec 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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