A multi-scale approach to understand the mechanobiology of intermediate filaments

Zhao Qin, Markus J. Buehler, Laurent Kreplak

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

The animal cell cytoskeleton consists of three interconnected filament systems: actin microfilaments, microtubules and the lesser known intermediate filaments (IFs). All mature IF proteins share a common tripartite domain structure and the ability to assemble into 8-12 nm wide filaments. At the time of their discovery in the 1980s, IFs were only considered as passive elements of the cytoskeleton mainly involved in maintaining the mechanical integrity of tissues. Since then, our knowledge of IFs structure, assembly plan and functions has improved dramatically. Especially, single IFs show a unique combination of extensibility, flexibility and toughness that is a direct consequence of their unique assembly plan. In this review we will first discuss the mechanical design of IFs by combining the experimental data with recent multi-scale modeling results. Then we will discuss how mechanical forces may interact with IFs in vivo both directly and through the activation of other proteins such as kinases.

Original languageEnglish (US)
Pages (from-to)15-22
Number of pages8
JournalJournal of Biomechanics
Volume43
Issue number1
DOIs
StatePublished - Jan 5 2010
Externally publishedYes

Keywords

  • Active remodeling
  • Molecular slippage
  • Multi-scale modeling
  • Shear stress
  • Stretch sensor
  • Tensile stress

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine
  • Biomedical Engineering
  • Rehabilitation

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