A micro device for measuring single-cell membrane specific capacitance and cytoplasm conductivity

Qingyuan Tan, Jian Chen, Yi Zheng, Brandon K. Chen, Yu Sun

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

This paper presents a micro device using micro electrical impedance spectroscopy (μEIS) to extract single-cell membrane specific capacitance and cytoplasm conductivity. Single cells were aspirated and stopped inside a wedge-shaped constriction channel where their impedance profiles were recorded by an impedance analyzer. An equivalent circuit model was developed to extract cell electrical parameters from the measured impedance profiles. The system was applied to quantify membrane specific capacitance (4.48±1.17 μF/cm 2, n=11) and cytoplasm conductivity (0.59±0.33 S/m, n=11) of PAVICs (porcine aortic valve interstitial cells).

Original languageEnglish (US)
Title of host publication2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
Pages757-760
Number of pages4
DOIs
StatePublished - 2012
Externally publishedYes
Event2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 - Paris, France
Duration: Jan 29 2012Feb 2 2012

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)1084-6999

Conference

Conference2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
Country/TerritoryFrance
CityParis
Period1/29/122/2/12

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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