A hybrid selection and testing procedure with curtailment for comparative clinical trials

Elena M. Buzaianu, Pinyuen Chen

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

In this paper we use the idea of strong curtailment to define a hybrid selection and testing procedure for finding the best among several experimental Bernoulli populations, provided that it is better than a control Bernoulli population. Our curtailment procedure is based on the fixed-sample-size selection and testing procedure proposed by Thall et al. (1988). Our curtailment procedure reaches the same probability of a correct selection as the original procedure, but requires fewer observations.

Original languageEnglish (US)
Pages (from-to)2-20
Number of pages19
JournalSequential Analysis
Volume28
Issue number1
DOIs
StatePublished - Jan 1 2009

Keywords

  • Bernoulli population
  • Better efficiency
  • Clinical trials
  • Correct selection
  • Curtailment
  • Sample size

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation

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