(Matrix presented) A strategy to restrict the highly flexible backbone conformation of a peptide nucleic acid (PNA) by incorporation of a cyclopentane ring is proposed. An asymmetric synthesis of cyclopentane-modified PNA is reported, and its binding properties were determined. The cyclopentane ring leads to a significant improvement in the binding properties of the resulting PNA to DNA and RNA.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Jul 24 2003|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry