A centriole's subdistal appendages: Contributions to cell division, ciliogenesis and differentiation

Nicole A. Hall, Heidi Hehnly

Research output: Contribution to journalArticlepeer-review

Abstract

The centrosome is a highly conserved structure composed of two centrioles surrounded by pericentriolar material. The mother, and inherently older, centriole has distal and subdistal appendages, whereas the daughter centriole is devoid of these appendage structures. Both appendages have been primarily linked to functions in cilia formation. However, subdistal appendages present with a variety of potential functions that include spindle placement, chromosome alignment, the final stage of cell division (abscission) and potentially cell differentiation. Subdistal appendages are particularly interesting in that they do not always display a conserved ninefold symmetry in appendage organization on the mother centriole across eukaryotic species, unlike distal appendages. In this review, we aim to differentiate both the morphology and role of the distal and subdistal appendages, with a particular focus on subdistal appendages.

Original languageEnglish (US)
Article number200399
JournalOpen Biology
Volume11
Issue number2
DOIs
StatePublished - Feb 2 2021

Keywords

  • centrosome
  • cilia
  • ciliopathies
  • division
  • midbody
  • subdistal appendages

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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