A Cellular Memory of Developmental History Generates Phenotypic Diversity in C. elegans

Sarah E Hall, Matthew Beverly, Carsten Russ, Chad Nusbaum, Piali Sengupta

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Early life experiences have a major impact on adult phenotypes [1-3]. However, the mechanisms by which animals retain a cellular memory of early experience are not well understood. Here we show that adult wild-type Caenorhabditis elegans that transiently pass through the stress-resistant dauer larval stage exhibit distinct gene expression profiles and life history traits, as compared to adult animals that bypassed this stage. Using chromatin immunoprecipitation experiments coupled with massively parallel sequencing, we found that genome-wide levels of specific histone tail modifications are markedly altered in postdauer animals. Mutations in subsets of genes implicated in chromatin remodeling abolish, or alter, the observed changes in gene expression and life history traits in postdauer animals. Modifications to the epigenome as a consequence of early experience may contribute in part to a memory of early experience and generate phenotypic variation in an isogenic population.

Original languageEnglish (US)
Pages (from-to)149-155
Number of pages7
JournalCurrent Biology
Volume20
Issue number2
DOIs
StatePublished - Jan 26 2010
Externally publishedYes

Fingerprint

Animals
Data storage equipment
chromatin
Gene expression
life history
Chromatin
life events
gene expression
animals
Histone Code
Genes
Caenorhabditis elegans
phenotypic variation
histones
High-Throughput Nucleotide Sequencing
Chromatin Assembly and Disassembly
Chromatin Immunoprecipitation
Life Change Events
tail
Transcriptome

Keywords

  • DEVBIO
  • DNA

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

A Cellular Memory of Developmental History Generates Phenotypic Diversity in C. elegans. / Hall, Sarah E; Beverly, Matthew; Russ, Carsten; Nusbaum, Chad; Sengupta, Piali.

In: Current Biology, Vol. 20, No. 2, 26.01.2010, p. 149-155.

Research output: Contribution to journalArticle

Hall, Sarah E ; Beverly, Matthew ; Russ, Carsten ; Nusbaum, Chad ; Sengupta, Piali. / A Cellular Memory of Developmental History Generates Phenotypic Diversity in C. elegans. In: Current Biology. 2010 ; Vol. 20, No. 2. pp. 149-155.
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