A branching process for virus survival

J. Theodore Cox, Rinaldo B. Schinazi

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Quasispecies theory predicts that there is a critical mutation probability above which a viral population will go extinct. Above this threshold the virus loses the ability to replicate the best-adapted genotype, leading to a population composed of low replicating mutants that is eventually doomed. We propose a new branching model that shows that this is not necessarily so. That is, a population composed of ever changing mutants may survive.

Original languageEnglish (US)
Pages (from-to)888-894
Number of pages7
JournalJournal of Applied Probability
Volume49
Issue number3
DOIs
StatePublished - Sep 2012

Keywords

  • Branching process
  • Evolution
  • Quasispecies
  • Random environment

ASJC Scopus subject areas

  • Statistics and Probability
  • Mathematics(all)
  • Statistics, Probability and Uncertainty

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