A branching process for virus survival

J. Theodore Cox; Rinaldo B. Schinazi

doi:10.1239/jap/1346955342

A branching process for virus survival

J. Theodore Cox, Rinaldo B. Schinazi

Department of Mathematics

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Quasispecies theory predicts that there is a critical mutation probability above which a viral population will go extinct. Above this threshold the virus loses the ability to replicate the best-adapted genotype, leading to a population composed of low replicating mutants that is eventually doomed. We propose a new branching model that shows that this is not necessarily so. That is, a population composed of ever changing mutants may survive.

Original language	English (US)
Pages (from-to)	888-894
Number of pages	7
Journal	Journal of Applied Probability
Volume	49
Issue number	3
DOIs	https://doi.org/10.1239/jap/1346955342
State	Published - Sep 2012

Keywords

Branching process
Evolution
Quasispecies
Random environment

ASJC Scopus subject areas

Statistics and Probability
General Mathematics
Statistics, Probability and Uncertainty

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10.1239/jap/1346955342

Cite this

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AB - Quasispecies theory predicts that there is a critical mutation probability above which a viral population will go extinct. Above this threshold the virus loses the ability to replicate the best-adapted genotype, leading to a population composed of low replicating mutants that is eventually doomed. We propose a new branching model that shows that this is not necessarily so. That is, a population composed of ever changing mutants may survive.

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KW - Quasispecies

KW - Random environment

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A branching process for virus survival

Abstract

Keywords

ASJC Scopus subject areas

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