22q11.2 deletion syndrome: Are motor deficits more than expected for IQ level?

Nancy J. Roizen, Anne M. Higgins, Kevin M. Antshel, Wanda Fremont, Robert Shprintzen, Wendy R. Kates

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Objective: To examine motor function in children with 22q11.2 deletion syndrome (22q11.2) and a Full Scale IQ (FSIQ) comparable control group. Study design: This study was part of a prospective study of neuropsychological function in children 9 to 15 years of age with 22q11.2 and community control subjects and included children from these two populations with comparable FSIQs. Results: Verbal IQs on the WISC-R for 40 children with 22q11.2 (88.4) and 24 community control subjects (87.2) were not different (P = .563). However, the performance IQs were (22q11.2; 81.1 vs community controls; 89.3; P < .001). On the Visual Motor Inventory, there was no difference between the standard scores of the two groups (22q11.2; 93.0 vs community control subjects; 98.1; P = .336) but on the motor coordination part of the Visual Motor Inventory, the scores of the 22q11.2 deletion syndrome group were lower (77.2 vs 89.3; P = .002). On the general neurologic examination (P = .906), the tone examination (P = .705), and the ball skills part of the Motor Battery, (P = .378), there were no differences. However, on the axial stability part of the Motor Battery, the children with 22q11.2 exhibited less good balance (P = .026). Conclusions: School-aged children with 22q11.2 have specific motor deficits in axial stability and graphomotor skills.

Original languageEnglish (US)
Pages (from-to)658-661
Number of pages4
JournalJournal of Pediatrics
Issue number4
StatePublished - Oct 2010
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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