TY - JOUR
T1 - 2-({3-[(2R,4S,5R)-4-Hydr-oxy-5-hydroxy-methyl-2,3,4,5-tetra-hydro-furan-2- yl]-5-methyl-2,6-dioxo-1,2,3,6-tetra-hydro-pyrimidin-1-yl}meth-yl)isoindoline-1, 3-dione
AU - Bartholomä, Mark Daniel
AU - Ouellette, Wayne
AU - Zubieta, Jon
PY - 2009
Y1 - 2009
N2 - The title compound, C19H19N3O7, is a thymidine derivative and serves as an inter-mediate in the synthesis of a 99m Tc radiolabeled nucleoside analog. Inter-molecular O - H⋯O hydrogen bonding is observed between the hydr-oxy functionalities of the ribose unit themselves as well as between a hydr-oxy group and an O atom of the phthalimide group of an adjacent mol-ecule. The mol-ecules are stacked on top of each other in the direction of the a axis. The crystal packing is further stabilized by weak intra- and inter-molecular C - H⋯O hydrogen bonds. The absolute configuration of the compound is known from the synthesis.
AB - The title compound, C19H19N3O7, is a thymidine derivative and serves as an inter-mediate in the synthesis of a 99m Tc radiolabeled nucleoside analog. Inter-molecular O - H⋯O hydrogen bonding is observed between the hydr-oxy functionalities of the ribose unit themselves as well as between a hydr-oxy group and an O atom of the phthalimide group of an adjacent mol-ecule. The mol-ecules are stacked on top of each other in the direction of the a axis. The crystal packing is further stabilized by weak intra- and inter-molecular C - H⋯O hydrogen bonds. The absolute configuration of the compound is known from the synthesis.
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U2 - 10.1107/S1600536809003365
DO - 10.1107/S1600536809003365
M3 - Article
C2 - 21582018
AN - SCOPUS:60349095175
SN - 1600-5368
VL - 65
SP - o432-o433
JO - Acta Crystallographica Section E: Structure Reports Online
JF - Acta Crystallographica Section E: Structure Reports Online
IS - 2
ER -