2-({3-[(2R,4S,5R)-4-Hydr-oxy-5-hydroxy-methyl-2,3,4,5-tetra-hydro-furan-2- yl]-5-methyl-2,6-dioxo-1,2,3,6-tetra-hydro-pyrimidin-1-yl}meth-yl)isoindoline-1, 3-dione

Mark Daniel Bartholomä, Wayne Ouellette, Jon Zubieta

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The title compound, C19H19N3O7, is a thymidine derivative and serves as an inter-mediate in the synthesis of a 99m Tc radiolabeled nucleoside analog. Inter-molecular O - H⋯O hydrogen bonding is observed between the hydr-oxy functionalities of the ribose unit themselves as well as between a hydr-oxy group and an O atom of the phthalimide group of an adjacent mol-ecule. The mol-ecules are stacked on top of each other in the direction of the a axis. The crystal packing is further stabilized by weak intra- and inter-molecular C - H⋯O hydrogen bonds. The absolute configuration of the compound is known from the synthesis.

Original languageEnglish (US)
Pages (from-to)o432-o433
JournalActa Crystallographica Section E: Structure Reports Online
Volume65
Issue number2
DOIs
StatePublished - Feb 23 2009

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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