β-(1-Azulenyl)-l-alanine-a functional probe for determination of pKa of histidine residues

Pallavi M. Gosavi, Yurii S. Moroz, Ivan V. Korendovych

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

β-(1-Azulenyl)-l-alanine (AzAla) can be incorporated into the influenza A virus M2 proton channel. AzAla's sensitivity to the protonation state of the nearby histidines and the lack of environmental fluorescence dependence allow for direct and straightforward determination of histidine pKa values in ion channels. This journal is

Original languageEnglish (US)
Pages (from-to)5347-5350
Number of pages4
JournalChemical Communications
Volume51
Issue number25
DOIs
StatePublished - Mar 28 2015

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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