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Research Output 2001 2019

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Article
2010
10 Citations (Scopus)

The binding of vitamin B12 to transcobalamin(II); Structural considerations for bioconjugate design - A molecular dynamics study

Allis, D. G., Fairchild, T. J. & Doyle, R. P., Sep 2010, In : Molecular BioSystems. 6, 9, p. 1611-1618 8 p.

Research output: Contribution to journalArticle

Transcobalamins
Molecular Dynamics Simulation
Vitamin B 12
Insulin
Ribose
2009
6 Citations (Scopus)

Anticancer conjugates and cocktails based on methotrexate and nucleoside synergism

Vortherms, A. R., Dang, H. N. & Doyle, R. P., 2009, In : Clinical Medicine: Oncology. 2009, 3, p. 19-26 8 p.

Research output: Contribution to journalArticle

Idoxuridine
Nucleosides
Methotrexate
Zalcitabine
Inhibitory Concentration 50
21 Citations (Scopus)

Exploring the implications of vitamin B12 conjugation to insulin on insulin receptor binding

Petrus, A. K., Allis, D. G., Smith, R. P., Fairchild, T. J. & Doyle, R. P., Mar 16 2009, In : ChemMedChem. 4, 3, p. 421-426 6 p.

Research output: Contribution to journalArticle

Insulin Receptor
Vitamin B 12
Insulin
Chemical modification
Blood Glucose
40 Citations (Scopus)

Pyrophosphate-bridged complexes with picomolar toxicity

Ikotun, O. F., Higbee, E. M., Ouellette, W. & Doyle, R. P., Sep 2009, In : Journal of Inorganic Biochemistry. 103, 9, p. 1254-1264 11 p.

Research output: Contribution to journalArticle

Toxicity
Cytotoxicity
Hydrolysis
Cells
Enzyme inhibition
56 Citations (Scopus)

Targeting the cubilin receptor through the vitamin B12 uptake pathway: Cytotoxicity and mechanistic insight through fluorescent Re(I) delivery

Viola-Villegas, N., Rabideau, A. E., Bartholoma, M., Zubieta, J. A. & Doyle, R. P., Aug 27 2009, In : Journal of Medicinal Chemistry. 52, 16, p. 5253-5261 9 p.

Research output: Contribution to journalArticle

Vitamin B 12
Intrinsic Factor
Rhenium
Choriocarcinoma
Biosensing Techniques
89 Citations (Scopus)
Metal complexes
acetic acid
Acetic acid
Acetic Acid
Contrast Media
89 Citations (Scopus)

Traveling the vitamin B12 pathway: Oral delivery of protein and peptide drugs

Petrus, A. K., Fairchild, T. J. & Doyle, R. P., Jan 26 2009, In : Angewandte Chemie (International Edition in English). 48, 6, p. 1022-1028 7 p.

Research output: Contribution to journalArticle

Vitamins
Vitamin B 12
Peptides
Proteins
Pharmaceutical Preparations
2008
18 Citations (Scopus)

Functional characterization and metal ion specificity of the metal-citrate complex transporter from Streptomyces coelicolor

Lensbouer, J. J., Patel, A., Sirianni, J. P. & Doyle, R. P., Aug 2008, In : Journal of Bacteriology. 190, 16, p. 5616-5623 8 p.

Research output: Contribution to journalArticle

Streptomyces coelicolor
Coordination Complexes
Citric Acid
Metals
Ions
22 Citations (Scopus)

On the evolutionary significance and metal-binding characteristics of a monolobal transferrin from Ciona intestinalis

Tinoco, A. D., Peterson, C. W., Lucchese, B., Doyle, R. P. & Valentine, A. M., Mar 4 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 9, p. 3268-3273 6 p.

Research output: Contribution to journalArticle

Transferrins
Ciona intestinalis
Transferrin
Metals
Proteins
5 Citations (Scopus)

Orthogonal ligation: A three piece assembly of a PNA-peptide-PNA conjugate

Burlina, F., Dixson, D. D., Doyle, R. P., Chassaing, G., Boddy, C. N., Dawson, P. & Offer, J., 2008, In : Chemical Communications. 24, p. 2785-2787 3 p.

Research output: Contribution to journalArticle

Peptides
34 Citations (Scopus)

Spin canting in an unprecedented three-dimensional pyrophosphate- and 2,2′-bipyrimidine-bridged cobalt(ii) framework

Marino, N., Mastropietro, T. F., Armentano, D., De Munno, G., Doyle, R. P., Lloret, F. & Julve, M., Sep 23 2008, In : Journal of the Chemical Society. Dalton Transactions. 38, p. 5152-5154 3 p.

Research output: Contribution to journalArticle

Cobalt compounds
Cobalt
Ligands
diphosphoric acid
13 Citations (Scopus)

Synthesis, characterization, and in vitro assay of folic acid conjugates of 3′-azido-3′-deoxythymidine (AZT): Toward targeted AZT based anticancer therapeutics

Vortherms, A. R., Doyle, R. P., Gao, D., Debrah, O. & Sinko, P. J., Feb 2008, In : Nucleosides, Nucleotides and Nucleic Acids. 27, 2, p. 173-185 13 p.

Research output: Contribution to journalArticle

Zidovudine
Folic Acid
Assays
Cells
Cell Line
13 Citations (Scopus)

Synthesis, structural, magnetic and thermal characterization of {[Cu(bipy)]2(μ-HP2O7)(μ-Cl)} ·H2O

Ikotun, O. F., Higbee, E. M., Ouellette, W., Lloret, F., Julve, M. & Doyle, R. P., Nov 2008, In : European Journal of Inorganic Chemistry. 33, p. 5281-5286 6 p.

Research output: Contribution to journalArticle

Copper
Hamiltonians
Magnetic couplings
Atoms
Molecular interactions
26 Citations (Scopus)

Synthesis, structural, thermal and magnetic characterization of a pyrophosphato-bridged cobalt(II) complex

Ikotun, O. F., Ouellette, W., Lloret, F., Kruger, P. E., Julve, M. & Doyle, R. P., Jun 2008, In : European Journal of Inorganic Chemistry. 17, p. 2691-2697 7 p.

Research output: Contribution to journalArticle

Cobalt
Ligands
Magnetic susceptibility
Metals
Magnetic couplings
11 Citations (Scopus)

Targeting gallium to cancer cells through the folate receptor

Viola-Villegas, N., Vortherms, A. & Doyle, R. P., 2008, In : Drug Target Insights. 2008, 3, p. 13-25 13 p.

Research output: Contribution to journalArticle

Gallium
Folic Acid
Cells
Polyethylene glycols
Neoplasms
56 Citations (Scopus)

Targeting the folate receptor (FR): Imaging and cytotoxicity of Re I conjugates in FR-overexpressing cancer cells

Viola-Villegas, N., Rabideau, A. E., Cesnavicious, J., Zubieta, J. A. & Doyle, R. P., Sep 15 2008, In : ChemMedChem. 3, 9, p. 1387-1394 8 p.

Research output: Contribution to journalArticle

Cytotoxicity
Folic Acid
Cells
Imaging techniques
Rhenium
2007
16 Citations (Scopus)

Metamorphosis of a butterfly: Synthesis, structural, thermal, magnetic and DFT characterisation of a ferromagnetically coupled tetranuclear copper(ii) complex

Doyle, R. P., Bauer, T., Julve, M., Lloret, F., Cano, J., Nieuwenhuyzen, M. & Kruger, P. E., 2007, In : Dalton Transactions. 44, p. 5140-5147 8 p.

Research output: Contribution to journalArticle

Discrete Fourier transforms
Copper
Water
Ligands
Molecules
13 Citations (Scopus)
Nickel
Dimers
X rays
Diffusion in liquids
Hamiltonians
37 Citations (Scopus)

Synthesis and structural and magnetic characterization of {[(phen) 2Ni]2(μ-P2O7)}·27H 2O and {[(phen)2Mn]2(μ-P2O 7)}·13H2O: Rare examples of coordination complexes with the pyrophosphate ligand

Ikotun, O. F., Armatus, N. G., Julve, M., Kruger, P. E., Lloret, F., Nieuwenhuyzen, M. & Doyle, R. P., Aug 6 2007, In : Inorganic Chemistry. 46, 16, p. 6668-6674 7 p.

Research output: Contribution to journalArticle

Phenanthrolines
Coordination Complexes
Ligands
ligands
metal ions
51 Citations (Scopus)

Vitamin B12 as a carrier for the oral delivery of insulin

Petrus, A. K., Vortherms, A. R., Fairchild, T. J. & Doyle, R. P., Dec 10 2007, In : ChemMedChem. 2, 12, p. 1717-1721 5 p.

Research output: Contribution to journalArticle

Vitamin B 12
Insulin
Patient Compliance
Medical problems
Oral Administration
2006
4 Citations (Scopus)

A molecular 'back-flip': The structural consequences of the crystal-to-crystal phase transition between [(phen)2CuCO 3]·11H2O and [(phen)2CuCO 3]·7H2O

Doyle, R. P., Nieuwenhuyzen, M. & Kruger, P. E., 2006, In : CrystEngComm. 8, 12, p. 904-908 5 p.

Research output: Contribution to journalArticle

Phase transitions
Crystals
bricks
Brick
crystals
26 Citations (Scopus)
Anions
Copper
Magnetic properties
Hydrogen bonds
Tuning
42 Citations (Scopus)

Synthesis, structure and thermal analysis of the gallium complex of 1,4,7,10-tetraazacyclo-dodecane-N,N′,N″,N‴-tetraacetic acid (DOTA)

Viola, N. A., Rarig, R. S., Ouellette, W. & Doyle, R. P., Dec 25 2006, In : Polyhedron. 25, 18, p. 3457-3462 6 p.

Research output: Contribution to journalArticle

Gallium
Thermoanalysis
gallium
thermal analysis
Hot Temperature
2005
35 Citations (Scopus)

Polynuclear complexes with bridging pyrophosphate ligands: Synthesis and characterisation of {[(bipy)Cu(H2O)

Doyle, R. P., Nieuwenhuyzen, M. & Kruger, P. E., Dec 7 2005, In : Dalton Transactions. 23, p. 3745-3750 6 p.

Research output: Contribution to journalArticle

Ligands
Water
Dimers
Inorganic Pyrophosphatase
Atoms
2003
4 Citations (Scopus)
Water
Ice
Magnetic susceptibility
Isomers
Dimers
45 Citations (Scopus)

Synthesis and structural and magnetic characterisation of tetranuclear Cu(II) complexes possessing novel [Cu4(μ4- PO4)2-(μ2-CO3)] butterfly cores that exhibit supramolecular isomerism

Doyle, R. P., Kruger, P. E., Moubaraki, B., Murray, K. S. & Nieuwenhuyzen, M., Nov 21 2003, In : Dalton Transactions. 22, p. 4230-4237 8 p.

Research output: Contribution to journalArticle

Water
Phenanthrolines
Ice
Magnetic susceptibility
Isomers
2002
20 Citations (Scopus)

A dihydrogen arsenate-mediated supramolecular network: Crystal structure and magnetic properties of {|(bipy)Cu(μ-H2AsO4)(H 2AsO4)|2}n

Doyle, R. P., Kruger, P. E., Julve, M., Lloret, F. & Nieuwenhuyzen, M., 2002, In : CrystEngComm. 4, 3, p. 13-16 4 p.

Research output: Contribution to journalArticle

arsenates
Magnetic susceptibility
Magnetic properties
Suspensions
Hydrogen bonds
2001
14 Citations (Scopus)

Phenazine-2,3-diamine

Doyle, R. P., Kruger, P. E., Mackie, P. R. & Nieuwenhuyzen, M., Jan 2001, In : Acta Crystallographica Section C: Crystal Structure Communications. 57, 1, p. 104-105 2 p.

Research output: Contribution to journalArticle

Diamines
diamines
chemistry
nuclear magnetic resonance
hydrogen
53 Citations (Scopus)

Structure and magnetic properties of a pyrophosphate-bridged Cu(II) complex

Kruger, P. E., Doyle, R. P., Julve, M., Lloret, F. & Nieuwenhuyzen, M., Apr 9 2001, In : Inorganic Chemistry. 40, 8, p. 1726-1727 2 p.

Research output: Contribution to journalArticle

Magnetic properties
magnetic properties
aqueous solutions
salts
Salts