If you made any changes in Pure, your changes will be visible here soon.

Research Output 2001 2019

Filter
Article
6 Citations (Scopus)

89Zr-Cobalamin PET Tracer: Synthesis, cellular uptake, and use for tumor imaging

Kuda-Wedagedara, A. N. W., Workinger, J. L., Nexo, E., Doyle, R. P. & Viola-Villegas, N., 2017, In : ACS Omega. 2, 10, p. 6314-6320 7 p.

Research output: Contribution to journalArticle

Vitamin B 12
Tumors
Imaging techniques
Cells
Positron emission tomography
20 Citations (Scopus)

A dihydrogen arsenate-mediated supramolecular network: Crystal structure and magnetic properties of {|(bipy)Cu(μ-H2AsO4)(H 2AsO4)|2}n

Doyle, R. P., Kruger, P. E., Julve, M., Lloret, F. & Nieuwenhuyzen, M., 2002, In : CrystEngComm. 4, 3, p. 13-16 4 p.

Research output: Contribution to journalArticle

arsenates
Magnetic susceptibility
Magnetic properties
Suspensions
Hydrogen bonds
13 Citations (Scopus)

Aging-related changes in the iron status of skeletal muscle

Deruisseau, K. C., Park, Y. M., DeRuisseau, L. R., Cowley, P. M., Fazen, C. H. & Doyle, R. P., Nov 2013, In : Experimental Gerontology. 48, 11, p. 1294-1302 9 p.

Research output: Contribution to journalArticle

Muscle
Skeletal Muscle
Iron
Aging of materials
Muscles
1 Citation (Scopus)

A methylenediphosphonate bridged copper(II) tetramer: Synthesis, structural, thermal, and magnetic characterization of [Cu4(H2O)2(phen)4(μ-P2O6CH2)2]·21H2O

Greenfield, T. J., Takemoto, T., Cano, J., Lloret, F., Julve, M., Zubieta, J. A. & Doyle, R. P., Sep 1 2019, In : Polyhedron. 169, p. 162-168 7 p.

Research output: Contribution to journalArticle

methylene
Copper
copper
synthesis
Organophosphonates
45 Citations (Scopus)

A modular phase transfer and ligand exchange protocol for quantum dots

Zylstra, J., Amey, J., Miska, N. J., Pang, L., Hine, C. R., Langer, J., Doyle, R. P. & Maye, M. M., Apr 19 2011, In : Langmuir. 27, 8, p. 4371-4379 9 p.

Research output: Contribution to journalArticle

Semiconductor quantum dots
Ligands
quantum dots
histidine
ligands
4 Citations (Scopus)

A molecular 'back-flip': The structural consequences of the crystal-to-crystal phase transition between [(phen)2CuCO 3]·11H2O and [(phen)2CuCO 3]·7H2O

Doyle, R. P., Nieuwenhuyzen, M. & Kruger, P. E., 2006, In : CrystEngComm. 8, 12, p. 904-908 5 p.

Research output: Contribution to journalArticle

Phase transitions
Crystals
bricks
Brick
crystals
6 Citations (Scopus)

Anticancer conjugates and cocktails based on methotrexate and nucleoside synergism

Vortherms, A. R., Dang, H. N. & Doyle, R. P., 2009, In : Clinical Medicine: Oncology. 2009, 3, p. 19-26 8 p.

Research output: Contribution to journalArticle

Idoxuridine
Nucleosides
Methotrexate
Zalcitabine
Inhibitory Concentration 50
7 Citations (Scopus)

Assessment of endothelial function and blood metabolite status following acute ingestion of a fructose-containing beverage

Bidwell, A. J., Holmstrup, M. E., Doyle, R. P. & Fairchild, T. J., Sep 2010, In : Acta Physiologica. 200, 1, p. 35-43 9 p.

Research output: Contribution to journalArticle

Beverages
Fructose
Eating
Glucose
Uric Acid
6 Citations (Scopus)

A vitamin B12 conjugate of exendin-4 improves glucose tolerance without associated nausea or hypophagia in rodents

Mietlicki-Baase, E. G., Liberini, C. G., Workinger, J. L., Bonaccorso, R. L., Borner, T., Reiner, D. J., Koch-Laskowski, K., Mcgrath, L. E., Lhamo, R., Stein, L. M., De Jonghe, B. C., Holz, G. G., Roth, C. L., Doyle, R. P. & Hayes, M. R., Jan 1 2018, (Accepted/In press) In : Diabetes, Obesity and Metabolism.

Research output: Contribution to journalArticle

Vitamin B 12
Nausea
Rodentia
Glucose
Penetrance
28 Citations (Scopus)

A water soluble vitamin B 12-Re(I) fluorescent conjugate for cell uptake screens: Use in the confirmation of cubilin in the lung cancer line A549

Vortherms, A. R., Kahkoska, A. R., Rabideau, A. E., Zubieta, J. A., Andersen, L. L., Madsen, M. & Doyle, R. P., Sep 21 2011, In : Chemical Communications. 47, 35, p. 9792-9794 3 p.

Research output: Contribution to journalArticle

Vitamins
Vitamin B 12
Cells
Rhenium
Intrinsic Factor
2 Citations (Scopus)

Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors

Chepurny, O. G., Bonaccorso, R. L., Leech, C. A., Wöllert, T., Langford, G. M., Schwede, F., Roth, C. L., Doyle, R. P. & Holz, G. G., Dec 1 2018, In : Scientific Reports. 8, 1, 3749.

Research output: Contribution to journalArticle

Glucagon-Like Peptide 1
Peptides
Appetite
Blood Glucose
Adenosine A2B Receptors
5 Citations (Scopus)

Clinical isolates of Candida albicans, Candida tropicalis, and Candida krusei have different susceptibilities to Co(II) and Cu(II) complexes of 1,10-phenanthroline

Hoffman, A. E., Miles, L., Greenfield, T. J., Shoen, C., Destefano, M., Cynamon, M. & Doyle, R. P., Apr 1 2015, In : BioMetals. 28, 2, p. 415-423 9 p.

Research output: Contribution to journalArticle

Candida tropicalis
Candida krusei
Candida
Candida albicans
Copper
25 Citations (Scopus)

Co(II) and Cu(II) pyrophosphate complexes have selectivity and potency against Mycobacteria including Mycobacteriumtuberculosis

Hoffman, A. E., DeStefano, M., Shoen, C., Gopinath, K., Warner, D. F., Cynamon, M. & Doyle, R. P., 2013, In : European Journal of Medicinal Chemistry. 70, p. 589-593 5 p.

Research output: Contribution to journalArticle

Mycobacterium
Tuberculosis
Cobalt
Copper
Metals
38 Citations (Scopus)

Coordination complexes incorporating pyrophosphate: Structural overview and exploration of their diverse magnetic, catalytic and biological properties

Ikotun, O. F., Marino, N., Kruger, P. E., Julve, M. & Doyle, R. P., Apr 2010, In : Coordination Chemistry Reviews. 254, 7-8, p. 890-915 26 p.

Research output: Contribution to journalArticle

Coordination Complexes
Negative ions
Ligands
magnetic properties
Biochemistry
1 Citation (Scopus)

Defining the origins of multiple emission/excitation in rhenium-bisthiazole complexes

Azzarelli, N., Ponnala, S., Aguirre, A., Dampf, S. J., Davis, M. P., Ruggiero, M. T., Lopez Diaz, V., Babich, J. W., Coogan, M., Korter, T. M., Doyle, R. P. & Zubieta, J. A., Apr 1 2019, In : Inorganica Chimica Acta. 489, p. 301-309 9 p.

Research output: Contribution to journalArticle

Rhenium
Thiazoles
Putrescine
rhenium
Carbon Monoxide
22 Citations (Scopus)

Emission wavelength variation with changes in excitation in a Re(i)-bisthiazole ligand complex that breaks the Kasha-Vavilov rule

Henry, K. E., Balasingham, R. G., Vortherms, A. R., Platts, J. A., Valliant, J. F., Coogan, M. P., Zubieta, J. A. & Doyle, R. P., Jun 2013, In : Chemical Science. 4, 6, p. 2490-2495 6 p.

Research output: Contribution to journalArticle

Carbon Monoxide
Rhenium
Ligands
Imaging techniques
Thiazoles
8 Citations (Scopus)

Enhanced Peptide Stability Against Protease Digestion Induced by Intrinsic Factor Binding of a Vitamin B12 Conjugate of Exendin-4

Bonaccorso, R. L., Chepurny, O. G., Becker-Pauly, C., Holz, G. G. & Doyle, R. P., Sep 8 2015, In : Molecular Pharmaceutics. 12, 9, p. 3502-3506 5 p.

Research output: Contribution to journalArticle

Intrinsic Factor
Vitamin B 12
Digestion
Peptide Hydrolases
Tiopronin
10 Citations (Scopus)

Examining the effects of vitamin B12 conjugation on the biological activity of insulin: A molecular dynamic and in vivo oral uptake investigation

Clardy-James, S., Allis, D. G., Fairchild, T. J. & Doyle, R. P., Sep 2012, In : MedChemComm. 3, 9, p. 1054-1058 5 p.

Research output: Contribution to journalArticle

Molecular Dynamics Simulation
Vitamin B 12
Bioactivity
Molecular dynamics
Insulin
14 Citations (Scopus)

Expanding monomeric pyrophosphate complexes beyond platinum

Marino, N., Vortherms, A. R., Hoffman, A. E. & Doyle, R. P., Aug 2 2010, In : Inorganic Chemistry. 49, 15, p. 6790-6792 3 p.

Research output: Contribution to journalArticle

Platinum
cultured cells
Stoichiometry
Doxorubicin
Cisplatin
21 Citations (Scopus)

Exploring the implications of vitamin B12 conjugation to insulin on insulin receptor binding

Petrus, A. K., Allis, D. G., Smith, R. P., Fairchild, T. J. & Doyle, R. P., Mar 16 2009, In : ChemMedChem. 4, 3, p. 421-426 6 p.

Research output: Contribution to journalArticle

Insulin Receptor
Vitamin B 12
Insulin
Chemical modification
Blood Glucose
2 Citations (Scopus)

Exploring the multiligand binding specificity of saposin B reveals two binding sites

Tinklepaugh, J., Smith, B. M., Hanlon, E., Zubieta, C., Bou-Abdallah, F. & Doyle, R. P., 2017, In : ACS Omega. 2, 10, p. 7141-7145 5 p.

Research output: Contribution to journalArticle

Saposins
Binding sites
Binding Sites
Ligands
Fluorescence spectroscopy
5 Citations (Scopus)

Expression and purification of human PYY(3-36) in Escherichia coli using a His-tagged small ubiquitin-like modifier fusion

Fazen, C. H., Kahkoska, A. R. & Doyle, R. P., Sep 2012, In : Protein Expression and Purification. 85, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

Ubiquitin
Peptide Hydrolases
Escherichia coli
Digestion
Factor Xa
7 Citations (Scopus)

Ferromagnetic Coupling in "Double-Bridged" Dihydrogenpyrophosphate Complexes of Cobalt(II) and Nickel(II)

Greenfield, T. J., Hoffman, A. E., Marino, N., Goos, A. G., Lloret, F., Julve, M. & Doyle, R. P., Jul 6 2015, In : Inorganic Chemistry. 54, 13, p. 6537-6546 10 p.

Research output: Contribution to journalArticle

Cobalt
Nickel
cobalt
Metals
nickel
18 Citations (Scopus)

Functional characterization and metal ion specificity of the metal-citrate complex transporter from Streptomyces coelicolor

Lensbouer, J. J., Patel, A., Sirianni, J. P. & Doyle, R. P., Aug 2008, In : Journal of Bacteriology. 190, 16, p. 5616-5623 8 p.

Research output: Contribution to journalArticle

Streptomyces coelicolor
Coordination Complexes
Citric Acid
Metals
Ions
26 Citations (Scopus)
Anions
Copper
Magnetic properties
Hydrogen bonds
Tuning
9 Citations (Scopus)

Investigation of a vitamin B12 conjugate as a PET imaging probe

Ikotun, O. F., Marquez, B. V., Fazen, C. H., Kahkoska, A. R., Doyle, R. P. & Lapi, S. E., 2014, In : ChemMedChem. 9, 6, p. 1244-1251 8 p.

Research output: Contribution to journalArticle

Positron emission tomography
Vitamin B 12
Positron-Emission Tomography
Imaging techniques
Nutrients
47 Citations (Scopus)

Isostructural Pd II and Pt II pyrophosphato complexes: Polymorphism and unusual bond character in d 8-d 8 systems

Marino, N., Fazen, C. H., Blakemore, J. D., Incarvito, C. D., Hazari, N. & Doyle, R. P., Mar 21 2011, In : Inorganic Chemistry. 50, 6, p. 2507-2520 14 p.

Research output: Contribution to journalArticle

polymorphism
Polymorphism
Crystals
crystals
Water
4 Citations (Scopus)

Just a Gut Feeling: Central Nervous Effects of Peripheral Gastrointestinal Hormones

Roth, C. L. & Doyle, R. P., 2017, In : Endocrine Development. 32, p. 100-123 24 p.

Research output: Contribution to journalArticle

Gastrointestinal Hormones
Emotions
Appetite Regulation
Obesity
Pediatric Obesity

Metal-citrate complex transport in Kineococcus radiotolerans

Huta, B. P., Miller, N. H., Robertson, E. L. & Doyle, R. P., Jan 1 2017, (Accepted/In press) In : Journal of Basic Microbiology.

Research output: Contribution to journalArticle

Coordination Complexes
Citric Acid
Metals
Calcium Citrate
Ions
8 Citations (Scopus)

Metal-citrate complex uptake and CitMHS transporters: From coordination chemistry to possible vaccine development

Huta, B., Lensboeur, J. J., Lowe, A. J., Zubieta, J. A. & Doyle, R. P., Dec 1 2012, In : Inorganica Chimica Acta. 393, p. 125-134 10 p.

Research output: Contribution to journalArticle

vaccines
transporter
Vaccines
citrates
Citric Acid
16 Citations (Scopus)

Metamorphosis of a butterfly: Synthesis, structural, thermal, magnetic and DFT characterisation of a ferromagnetically coupled tetranuclear copper(ii) complex

Doyle, R. P., Bauer, T., Julve, M., Lloret, F., Cano, J., Nieuwenhuyzen, M. & Kruger, P. E., 2007, In : Dalton Transactions. 44, p. 5140-5147 8 p.

Research output: Contribution to journalArticle

Discrete Fourier transforms
Copper
Water
Ligands
Molecules
1 Citation (Scopus)

Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP

Chepurny, O. G., Matsoukas, M. T., Liapakis, G., Leech, C. A., Milliken, B. T., Doyle, R. P. & Holz, G. G., Mar 8 2019, In : The Journal of biological chemistry. 294, 10, p. 3514-3531 18 p.

Research output: Contribution to journalArticle

Open Access
Glucagon
Assays
Throughput
Glucagon-Like Peptide 1
G-Protein-Coupled Receptors
22 Citations (Scopus)

On the evolutionary significance and metal-binding characteristics of a monolobal transferrin from Ciona intestinalis

Tinoco, A. D., Peterson, C. W., Lucchese, B., Doyle, R. P. & Valentine, A. M., Mar 4 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 9, p. 3268-3273 6 p.

Research output: Contribution to journalArticle

Transferrins
Ciona intestinalis
Transferrin
Metals
Proteins
25 Citations (Scopus)

Oral delivery of the appetite suppressing peptide hPYY(3-36) through the Vitamin B 12 uptake pathway

Fazen, C. H., Valentin, D., Fairchild, T. J. & Doyle, R. P., Dec 22 2011, In : Journal of Medicinal Chemistry. 54, 24, p. 8707-8711 5 p.

Research output: Contribution to journalArticle

Appetite Regulation
Appetite
Vitamin B 12
Weight Loss
Peptides
5 Citations (Scopus)

Orthogonal ligation: A three piece assembly of a PNA-peptide-PNA conjugate

Burlina, F., Dixson, D. D., Doyle, R. P., Chassaing, G., Boddy, C. N., Dawson, P. & Offer, J., 2008, In : Chemical Communications. 24, p. 2785-2787 3 p.

Research output: Contribution to journalArticle

Peptides
14 Citations (Scopus)

Phenazine-2,3-diamine

Doyle, R. P., Kruger, P. E., Mackie, P. R. & Nieuwenhuyzen, M., Jan 2001, In : Acta Crystallographica Section C: Crystal Structure Communications. 57, 1, p. 104-105 2 p.

Research output: Contribution to journalArticle

Diamines
diamines
chemistry
nuclear magnetic resonance
hydrogen
35 Citations (Scopus)

Polynuclear complexes with bridging pyrophosphate ligands: Synthesis and characterisation of {[(bipy)Cu(H2O)

Doyle, R. P., Nieuwenhuyzen, M. & Kruger, P. E., Dec 7 2005, In : Dalton Transactions. 23, p. 3745-3750 6 p.

Research output: Contribution to journalArticle

Ligands
Water
Dimers
Inorganic Pyrophosphatase
Atoms
40 Citations (Scopus)

Pyrophosphate-bridged complexes with picomolar toxicity

Ikotun, O. F., Higbee, E. M., Ouellette, W. & Doyle, R. P., Sep 2009, In : Journal of Inorganic Biochemistry. 103, 9, p. 1254-1264 11 p.

Research output: Contribution to journalArticle

Toxicity
Cytotoxicity
Hydrolysis
Cells
Enzyme inhibition
41 Citations (Scopus)

Pyrophosphate-mediated magnetic interactions in Cu(II) coordination complexes

Marino, N., Ikotun, O. F., Julve, M., Lloret, F., Cano, J. & Doyle, R. P., Jan 3 2011, In : Inorganic Chemistry. 50, 1, p. 378-389 12 p.

Research output: Contribution to journalArticle

Coordination Complexes
amines
Amines
interactions
metals
9 Citations (Scopus)

Pyro without fire: Synthesis, structure, and reactivity of a dimeric vanadyl pyrophosphate coordination complex

Marino, N., Hanson, S. K., Müller, P. & Doyle, R. P., Oct 1 2012, In : Inorganic Chemistry. 51, 19, p. 10077-10079 3 p.

Research output: Contribution to journalArticle

Benzyl Alcohol
Nanocrystalline powders
Vanadates
Coordination Complexes
catalytic activity
4 Citations (Scopus)

R161, K452 and R460 residues are vital for metal-citrate complex transport in CitSc from streptomyces coelicolor

Lensbouer, J. J., Li, Q. W., Estlinbaum, M. & Doyle, R. P., 2010, In : Metallomics. 2, 5, p. 342-347 6 p.

Research output: Contribution to journalArticle

Streptomyces coelicolor
Coordination Complexes
Citric Acid
Metals
Membrane Transport Proteins
5 Citations (Scopus)

Recombinant expression of His-tagged saposin B and pH-dependent binding to the lipid coenzyme Q10

Dixson, D. D., Yu, V. Y. & Doyle, R. P., Dec 15 2011, In : Analytical Biochemistry. 419, 2, p. 145-152 8 p.

Research output: Contribution to journalArticle

coenzyme Q10
Saposins
Lipids
Affinity chromatography
1 Citation (Scopus)

Recombinant manganese peroxidase reduces A2E burden in age-related and stargardt's macular degeneration models

Moody, K. J., Tinklepaugh, J., Obert, E., Grohn, K., Derosa, J. R., Lumen, E., Moyer, B. S., Campbell, S., Wolfe, A. J., Sleeper, M. B., Bianchi, A. H., Fisher, C., Applegate, J., Leary, E., Leclair, N., Wortel, D., Doyle, R. P., Rohrer, B. & Blanden, A. R., Dec 1 2018, In : Rejuvenation Research. 21, 6, p. 560-571 12 p.

Research output: Contribution to journalArticle

manganese peroxidase
Macular Degeneration
Enzyme Therapy
Retinoids
Enzyme Replacement Therapy
9 Citations (Scopus)

Reinvestigation of coenzyme Q10 isolation from sporidiobolus johnsonii

Dixson, D. D., Boddy, C. N. & Doyle, R. P., Jun 2011, In : Chemistry and Biodiversity. 8, 6, p. 1033-1051 19 p.

Research output: Contribution to journalArticle

coenzyme Q10
Coenzymes
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Thin layer chromatography
Biosynthesis
9 Citations (Scopus)

Secondary transport of metalcitrate complexes: The CitMHS family

Lensbouer, J. J. & Doyle, R. P., Oct 2010, In : Critical Reviews in Biochemistry and Molecular Biology. 45, 5, p. 453-462 10 p.

Research output: Contribution to journalArticle

Metal ions
Bacteria
Bioremediation
Citric Acid
Escherichia coli
27 Citations (Scopus)
Carbon Monoxide
Rhenium
Fluorescence
Amino Acids
Ligands
10 Citations (Scopus)

Site-selective oxidation of vitamin B12 using 2-iodoxybenzoic acid

Clardy-James, S., Bernstein, J. L., Kerwood, D. J. & Doyle, R. P., 2012, In : Synlett. 23, 16, p. 2363-2366 4 p., ST-2012-R0524-L.

Research output: Contribution to journalArticle

Vitamin B 12
Nuclear magnetic resonance
Derivatives
Oxidation
Ribose
7 Citations (Scopus)

Solution Structure and Constrained Molecular Dynamics Study of Vitamin B12 Conjugates of the Anorectic Peptide PYY(3-36)

Henry, K. E., Kerwood, D. J., Allis, D. G., Workinger, J. L., Bonaccorso, R. L., Holz, G. G., Roth, C. L., Zubieta, J. A. & Doyle, R. P., 2016, (Accepted/In press) In : ChemMedChem.

Research output: Contribution to journalArticle

Appetite Depressants
Molecular Dynamics Simulation
Vitamin B 12
Molecular dynamics
Peptides
34 Citations (Scopus)

Spin canting in an unprecedented three-dimensional pyrophosphate- and 2,2′-bipyrimidine-bridged cobalt(ii) framework

Marino, N., Mastropietro, T. F., Armentano, D., De Munno, G., Doyle, R. P., Lloret, F. & Julve, M., Sep 23 2008, In : Journal of the Chemical Society. Dalton Transactions. 38, p. 5152-5154 3 p.

Research output: Contribution to journalArticle

Cobalt compounds
Cobalt
Ligands
diphosphoric acid
53 Citations (Scopus)

Structure and magnetic properties of a pyrophosphate-bridged Cu(II) complex

Kruger, P. E., Doyle, R. P., Julve, M., Lloret, F. & Nieuwenhuyzen, M., Apr 9 2001, In : Inorganic Chemistry. 40, 8, p. 1726-1727 2 p.

Research output: Contribution to journalArticle

Magnetic properties
magnetic properties
aqueous solutions
salts
Salts